Results 101 to 110 of about 73,053 (252)
Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker +19 morewiley +1 more sourceExtrasolar Planet Transits Observed at Kitt Peak National Observatory
, 2012 We obtained J-, H- and JH-band photometry of known extrasolar planet
transiting systems at the 2.1-m Kitt Peak National Observatory Telescope using
the FLAMINGOS infrared camera between October 2008 and October 2011.Allen Lunsford, Brian k. Jackson, Catrina M. Hamilton, Claret A., Donald E. Jennings, Drake Deming, Eamon O’Gorman, Flynn Haase, Hirano T., Jonathan Fraine, Kevin Bays, Krejčová T., Lee J. W., Narita N., Narita N., Pedro V. Sada, Steven W. Peterson, Szabó Gy. M., Vereš P. +18 morecore +1 more sourceThe TESS-Keck Survey. XVII. Precise Mass Measurements in a Young, High-multiplicity Transiting Planet System Using Radial Velocities and Transit Timing Variations
The Astronomical JournalWe present a radial velocity (RV) analysis of TOI-1136, a bright Transiting Exoplanet Survey Satellite (TESS) system with six confirmed transiting planets, and a seventh single-transiting planet candidate.Corey Beard, Paul Robertson, Fei Dai, Rae Holcomb, Jack Lubin, Joseph M. Akana Murphy, Natalie M. Batalha, Sarah Blunt, Ian Crossfield, Courtney Dressing, Benjamin Fulton, Andrew W. Howard, Dan Huber, Howard Isaacson, Stephen R. Kane, Grzegorz Nowak, Erik A Petigura, Arpita Roy, Ryan A. Rubenzahl, Lauren M. Weiss, Rafael Barrena, Aida Behmard, Casey L. Brinkman, Ilaria Carleo, Ashley Chontos, Paul A. Dalba, Tara Fetherolf, Steven Giacalone, Michelle L. Hill, Kiyoe Kawauchi, Judith Korth, Rafael Luque, Mason G. MacDougall, Andrew W. Mayo, Teo Močnik, Giuseppe Morello, Felipe Murgas, Jaume Orell-Miquel, Enric Palle, Alex S. Polanski, Malena Rice, Nicholas Scarsdale, Dakotah Tyler, Judah Van Zandt +43 moredoaj +1 more sourceChemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam +14 morewiley +1 more sourceSuper-Earths: A New Class of Planetary Bodies
, 2011 Super-Earths, a class of planetary bodies with masses ranging from a few
Earth-masses to slightly smaller than Uranus, have recently found a special
place in the exoplanetary science.Armitage P. J., Christensen U. R., Clubb K., Dobrovolskis A. R., Fogg M. J., Ford E.B., Goldreich P., Haghighipour N., Haghighipour N., Hatzes A.P., Heng K., Michael S., Nader Haghighipour, Safronov V. S., Smoluchowski M. V., Sotin C., Stamenkovic V., Stamenkovic V., Steffen J. H., Swift D. C., Tackley P. J., Weidenschilling S. J. +21 morecore +1 more sourceA Fourth Planet in the Kepler-51 System Revealed by Transit Timing Variations
The Astronomical JournalKepler-51 is a ≲1 Gyr old Sun-like star hosting three transiting planets with radii ≈6–9 R _⊕ and orbital periods ≈45–130 days. Transit timing variations (TTVs) measured with past Kepler and Hubble Space Telescope (HST) observations have been ...Kento Masuda, Jessica E. Libby-Roberts, John H. Livingston, Kevin B. Stevenson, Peter Gao, Shreyas Vissapragada, Guangwei Fu, Te Han, Michael Greklek-McKeon, Suvrath Mahadevan, Eric Agol, Aaron Bello-Arufe, Zachory Berta-Thompson, Caleb I. Cañas, Yayaati Chachan, Leslie Hebb, Renyu Hu, Yui Kawashima, Heather A. Knutson, Caroline V. Morley, Catriona A. Murray, Kazumasa Ohno, Armen Tokadjian, Xi Zhang, Luis Welbanks, Matthew C. Nixon, Richard Freedman, Norio Narita, Akihiko Fukui, Jerome P. de Leon, Mayuko Mori, Enric Palle, Felipe Murgas, Hannu Parviainen, Emma Esparza-Borges, Daniel Jontof-Hutter, Karen A. Collins, Paul Benni, Khalid Barkaoui, Francisco J. Pozuelos, Michaël Gillon, Emmanuël Jehin, Zouhair Benkhaldoun, Suzanne Hawley, Andrea S. J. Lin, Guđmundur Stefánsson, Allyson Bieryla, Mesut Yilmaz, Hakan Volkan Senavci, Eric Girardin, Giuseppe Marino, Gavin Wang +51 moredoaj +1 more sourceTonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes +17 morewiley +1 more sourceGiant Outer Transiting Exoplanet Mass (GOT ‘EM) Survey. IV. Long-term Doppler Spectroscopy for 11 Stars Thought to Host Cool Giant Exoplanets
The Astrophysical Journal Supplement SeriesDiscovering and characterizing exoplanets at the outer edge of the transit method’s sensitivity has proven challenging owing to geometric biases and the practical difficulties associated with acquiring long observational baselines.Paul A. Dalba, Stephen R. Kane, Howard Isaacson, Benjamin Fulton, Andrew W. Howard, Edward W. Schwieterman, Daniel P. Thorngren, Jonathan Fortney, Noah Vowell, Corey Beard, Sarah Blunt, Casey L. Brinkman, Ashley Chontos, Fei Dai, Steven Giacalone, Michelle L. Hill, Molly Kosiarek, Jack Lubin, Andrew W. Mayo, Teo Močnik, Joseph M. Akana Murphy, Erik A. Petigura, Malena Rice, Ryan A. Rubenzahl, Judah Van Zandt, Lauren M. Weiss, Diana Dragomir, David Kipping, Matthew J. Payne, Arpita Roy, Alex Teachey, Steven Villanueva Jr. +31 moredoaj +1 more sourceDetecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda +12 morewiley +1 more sourceInvestigating the Atmospheric Mass Loss of the Kepler-105 Planets Straddling the Radius Gap
The Astronomical JournalAn intriguing pattern among exoplanets is the lack of detected planets between approximately 1.5 R _⊕ and 2.0 R _⊕ . One proposed explanation for this “radius gap” is the photoevaporation of planetary atmospheres, a theory that can be tested by studying ...Aaron Householder, Lauren M. Weiss, James E. Owen, Howard Isaacson, Andrew W. Howard, Daniel Fabrycky, Leslie A. Rogers, Hilke E. Schlichting, Benjamin J. Fulton, Erik A. Petigura, Steven Giacalone, Joseph M. Akana Murphy, Corey Beard, Ashley Chontos, Fei Dai, Judah Van Zandt, Jack Lubin, Malena Rice, Alex S. Polanski, Paul Dalba, Sarah Blunt, Emma V. Turtelboom, Ryan Rubenzahl, Casey Brinkman +23 moredoaj +1 more source
