Results 101 to 110 of about 76,246 (270)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
TOI-2015 b: A Warm Neptune with Transit Timing Variations Orbiting an Active Mid-type M Dwarf
The Astronomical JournalWe report the discovery of a close-in ( P _orb = 3.349 days) warm Neptune with clear transit timing variations (TTVs) orbiting the nearby ( d = 47.3 pc) active M4 star, TOI-2015.
Sinclaire E. Jones +31 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Kepler-1624b Has No Significant Transit Timing Variations
The Astronomical JournalIt is relatively rare for gas giant planets to have resonant or near-resonant companions, but these systems are particularly useful for constraining planet formation and migration models. In this study, we examine Kepler-1624b, a sub-Saturn orbiting an M
Haedam Im +11 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Modeling the Solar System. I. Characterization Limits from Analytic Timing Variations
The Planetary Science JournalPlanetary systems with multiple transiting planets are beneficial for understanding planet occurrence rates and system architectures. Although we have yet to find a solar system (SS) analog, future surveys may detect multiple terrestrial planets ...
Bethlee M. Lindor, Eric Agol
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
APPLICATION OF TRANSIT TIMING VARIATION METHOD (TTV) TO EXOPLANET SYSTEM TrES-3
, 2018 On the basis of the original photometricdata, the light curves of several transits in the exoplanet system TrES-3 were simulated by Monte Carlo method.Using these curves, the estimates of precise values of mid-transit time were calculated to assess the possibility offinding new planets by timing method in already known exoplanet systems using ground ...
openaire +1 more source