Results 101 to 110 of about 75,518 (268)
Modeling the Solar System. I. Characterization Limits from Analytic Timing Variations
The Planetary Science JournalPlanetary systems with multiple transiting planets are beneficial for understanding planet occurrence rates and system architectures. Although we have yet to find a solar system (SS) analog, future surveys may detect multiple terrestrial planets ...
Bethlee M. Lindor, Eric Agol
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
APPLICATION OF TRANSIT TIMING VARIATION METHOD (TTV) TO EXOPLANET SYSTEM TrES-3
, 2018 On the basis of the original photometricdata, the light curves of several transits in the exoplanet system TrES-3 were simulated by Monte Carlo method.Using these curves, the estimates of precise values of mid-transit time were calculated to assess the possibility offinding new planets by timing method in already known exoplanet systems using ground ...
openaire +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The Astrophysical JournalTidal interactions are one of the primary drivers of orbital evolution for massive planets with short orbital periods. Tidal dissipation within host stars can cause the orbits of such planets to decay.
Noah Sodickson, Samuel Grunblatt
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source