Results 31 to 40 of about 5,805 (230)
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
The Astrophysical JournalTransit timing variation (TTV) is a useful tool for studying the orbital properties of transiting objects. However, few TTV studies have been done on transiting brown dwarfs (BDs) around solar-type stars.
Wenqin Wang +5 more
doaj +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
A Transiting Giant on a 7.7 yr Orbit Revealed by Transit Timing Variations in the TOI-201 System
The Astrophysical Journal LettersWe report the detection and characterization of TOI-201 c, a long-period transiting companion to the warm Jupiter TOI-201 b. Its presence was first inferred from high-amplitude transit timing variations (TTVs) in TOI-201 b, pointing to a massive outer ...
Gracjan Maciejewski, Weronika Łoboda
doaj +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Validation of a Third Planet in the LHS 1678 System
The Astronomical JournalThe nearby LHS 1678 (TOI-696) system contains two confirmed planets and a wide-orbit, likely brown-dwarf companion, which orbit an M2 dwarf with a unique evolutionary history. The host star occupies a narrow “gap” in the Hertzsprung–Russell diagram lower
Michele L. Silverstein +26 more
doaj +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The Astronomical JournalThe ExoEcho project is designed to study the photodynamics of exoplanets by leveraging high-precision transit timing data from ground- and space-based telescopes.
Xinyue Ma +8 more
doaj +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source