Results 61 to 70 of about 158,251 (314)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Transitional Phenomenon in Metal Cutting
Bulletin of JSME, 1960 Abstract To analyze the metal cutting mechanism in the transitional cutting stage after first contact between the cutting tool and the work material, the theory of pseudo-steady plastic flow was applied. Determining the relation between friction angle on tool face and cutting time by cutting test, the change of cutting mechanism during the transitional
OKUSHIMA, Keiji, HITOMI, Katsundo
openaire +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Critical enhancement of the spin Hall effect by spin fluctuations
npj Quantum MaterialsThe spin Hall (SH) effect, the conversion of the electric current to the spin current along the transverse direction, relies on the relativistic spin-orbit coupling (SOC).
Satoshi Okamoto, Naoto Nagaosa
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Raman spectroscopy on transition metals
, 2007 Surface-enhanced Raman spectroscopy (SERS) has developed into one of the most important tools in analytical and surface sciences since its discovery in the mid-1970s.
Tian, Zhong-Qun +6 more
core +1 more source
Transfer Hydrogenation: Advances in Manganese and Nickel Metal Catalysis
Journal of ChemistryTransfer hydrogenation (TH) of ketones, catalyzed by transition–metal complexes, produces alcohols, which are important building blocks in the pharmaceutical and fine chemical industries. For a long time, catalysts based on noble metals such as ruthenium,
James Kamau +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
AtmosphereClimate change and global warming have been shown to increase the frequency and intensity of extreme weather events. Concurrently, substantial efforts are being directed toward fostering the transition to a low-carbon economy.
Ousama Ben-Salha +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source