Results 81 to 90 of about 1,119,090 (297)

Linking Radiative‐Advective Equilibrium Regime Transition to Arctic Amplification

open access: yesGeophysical Research Letters
Emission of anthropogenic greenhouse gases has resulted in greater Arctic warming compared to global warming, known as Arctic amplification (AA). From an energy‐balance perspective, the current Arctic climate is in radiative‐advective equilibrium (RAE ...
Yu‐Chiao Liang   +5 more
doaj   +1 more source

Poland’s Renewable Energy Transition (2010–2023): A Fuzzy Time Series and Multi-Criteria Assessment of Transition Quality in Electricity Production

open access: yesEnergies
This study evaluates the quality and dynamics of the renewable energy transition in Poland’s electricity sector during the years 2010–2023 through an integrated Fuzzy Time Series (FTS) and Fuzzy Multi-Criteria Evaluation (FMCE) methodology.
Bożena Gajdzik   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Effects of counterion fluctuations in a polyelectrolyte brush

open access: yes, 2003
We investigate the effect of counterion fluctuations in a single polyelectrolyte brush in the absence of added salt by systematically expanding the counterion free energy about Poisson-Boltzmann mean field theory.
A. W. C. Lau   +29 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Brownian Motion near Hydrodynamic-Regime Transitions

open access: yesPhysical Review Letters, 1976
The diffusion coefficient of suspended Brownian particles diverges near a hydrodynamicregime transition point. © 1976 The American Physical Society.
Lekkerkerker, Henk N W   +1 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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