Results 81 to 90 of about 967,077 (276)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
From momentarity to perfective multiplicity. Different aspects of the aorist
Cognitive Studies | Études cognitives, 2015 From momentarity to perfective multiplicity. Different aspects of the aorist The aim of this work is a analysis of temporal meanings, and aspectual research.
Joanna Satoła-Staśkowiak
doaj +1 more source
Strong and Weak Interpretations in Translating Chinese Poetry
, 2017 Are classical Chinese and modern Chinese one language, or two? Is translating classical Chinese poetry the same as or different from translating modern Chinese poetry?
KLEIN, Lucas
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Maintaining Source Language in Translating Holy Book: A Case of Translating Al-Qur‟an into Indonesian [PDF]
, 2011 Translation involves two or more languages in practice. This undoubtedly activates the conflict between the source and target language. When translator tries to help readers understand fully the concept of the source text, he will sacrifice the source ...
Baharuddin, Baharuddin
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
"Athletic Identity Measurement Scale": Translation, Adaptation and Validation for Brazil
Motriz: Revista de Educacao Fisica, 2016 The aim of this study was to translate, adapt and validate the version of the Athletic Identity Measurement Scale (AIMS) for Brazilian Portuguese. The methodological procedures were conducted according to international recommendations: translation, back ...
Walan Robert da Silva +5 more
doaj +1 more source
Winding Down the Atlantic Philanthropies: 2009-2010: Beginning the End Game [PDF]
, 2012 Reviews late-term program planning, including envisioning the end of the foundation and translating that vision into concrete plans. Examines challenges and opportunities for final grantmaking in the Population Health and Children and Youth ...
Tony Proscio
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source