Results 61 to 70 of about 37,229 (266)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

The communist censorship and the reception of Dostoevsky in the Romanian literary consciousness [PDF]

open access: yesPolis: Revista de Stiinte Politice, 2015
During the communist regime, the process of translating, publishing and interpreting Dostoevsky’s works has been heterogeneously: decades of being almost forbidden have alternated with moments when his novels have been widely published and promoted ...
Mihai VACARIU
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

AUTHENTIC MATERIALS’ ROLE WHEN TEACHING LAW-STUDENTS PROFESSIONAL TRANSLATION

open access: yesPolylinguality and Transcultural Practices, 2015
The article touches upon the issue of teaching professional English / Russian translation to law students of non-linguistic Universities. The brief analysis of authentic materials, the principle of their selection and their role in teaching English for ...
T V Emelyanova, A B Kostromin
doaj  

Gender-fair language in simultaneous interpreting: how EU interpreters cope with guidelines and innovations

open access: yesLinguistik Online
Integrating gender-fair language in spoken multilingual settings presents communication challenges such as cross-linguistic constraints. In simultaneous interpreting, the fast-paced and cognitively demanding nature of the task may limit compliance with ...
Igor Facchini
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Translational Models of Arrhythmia Mechanisms and Susceptibility: Success and Challenges of Modeling Human Disease

open access: yesFrontiers in Cardiovascular Medicine, 2019
We discuss large animal translational models of arrhythmia susceptibility and sudden cardiac death, focusing on important considerations when interpreting the data derived before applying them to human trials.
Joseph S. Piktel, Lance D. Wilson
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Exploring the Representational Competence of Eleventh-Grade Students on the Rates of Chemical Reactions

open access: yesJurnal Pendidikan IPA Indonesia
Representational competence is a key component in learning chemistry, allowing students to interpret and apply multiple forms of representations to explain scientific phenomena.
Thetipat Phajan   +2 more
doaj   +1 more source

Certificate Translation in Abstract Interpretation [PDF]

open access: yes, 2008
A certificate is a mathematical object that can be used to establish that a piece of mobile code satisfies some security policy. Since in general certificates cannot be generated automatically, there is an interest in developing methods to reuse certificates.
Gilles Barthe, César Kunz
openaire   +1 more source

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