Results 81 to 90 of about 245,702 (376)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
The Discourse on the Praxis and Pragmatics of the Qur’an Retranslations in Turkish
TranscUlturAl, 2020 Retranslations of the Qur’an constitute an intriguing site of research with particular premises governing their production, dissemination and/or reception in Turkey.
Sema Üstün Külünk
doaj +1 more source
Computational approaches to interpreting genomic sequence variation
Genome Medicine, 2014 Identifying sequence variants that play a mechanistic role in human disease and other phenotypes is a fundamental goal in human genetics and will be important in translating the results of variation studies.
G. Ritchie, Paul Flicek
semanticscholar +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Techniques of Translating Thesis Abstracts of Economics Department Students in Medan State University [PDF]
, 2015 The study deals with the techniques of translation on thesis abstracts inEconomics Department. The objectives of study were to identify the types oftranslation techniques, to find out the most dominant type of translationtechniques used, and to describe ...
Siregar, S. F. (Sofyan)
core
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Empirical Modelling Of Translation And Interpreting
, 2017 Empirical research is carried out in a cyclic way: approaching a research area bottom-up, data lead to interpretations and ideally to the abstraction of laws, on the basis of which a theory can be derived. Deductive research is based on a theory, on the basis of which hypotheses can be formulated and tested against the background of empirical data ...
Hansen-Schirra, Silvia +2 more
openaire +3 more sources
Competences in Translation and Interpreting
Studies About Languages, 2012 This paper examines competences in translation and interpreting that students have to acquire in University studies and need for translator’s or interpreter’s jobs in the European Union (EU) institutions. The research is based on the analysis of responses obtained independently by two questioners. The survey was designed in accordance with the European
Ligija Kaminskienė +1 more
openaire +2 more sources
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source