Results 91 to 100 of about 5,227,080 (312)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Evaluative reports on medical malpractice policies in obstetrics: a rapid scoping review

Systematic Reviews, 2017
Background The clinical specialty of obstetrics is under particular scrutiny with increasing litigation costs and unnecessary tests and procedures done in attempts to prevent litigation.
Roberta Cardoso, Wasifa Zarin, Vera Nincic, Sarah Louise Barber, Ahmet Metin Gulmezoglu, Charlotte Wilson, Katherine Wilson, Heather McDonald, Meghan Kenny, Rachel Warren, Sharon E. Straus, Andrea C. Tricco   +11 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Mesenchymal stromal cells for the prophylaxis and treatment of graft-versus-host disease—a meta-analysis

Stem Cell Research & Therapy, 2020
Background Graft-versus-host disease (GvHD) is the main life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). Thirty to 80% of GvHD patients do not respond to first-line treatment and a second-line treatment is not ...
Cynthia Morata-Tarifa, María del Mar Macías-Sánchez, Antonio Gutiérrez-Pizarraya, Rosario Sanchez-Pernaute   +3 more
doaj   +1 more source

Accuracy-based scoring for phrase-based statistical machine translation [PDF]

, 2010
Although the scoring features of state-of-the-art Phrase-Based Statistical Machine Translation (PB-SMT) models are weighted so as to optimise an objective function measuring translation quality, the estimation of the features themselves does not have ...
Galron, Daniel, Ma, Yanjun, Penkale, Sergio, Way, Andy   +3 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Building a resource for studying translation shifts [PDF]

, 2006
This paper describes an interdisciplinary approach which brings together the fields of corpus linguistics and translation studies. It presents ongoing work on the creation of a corpus resource in which translation shifts are explicitly annotated ...
Cyrus, Lea
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Translating translation [PDF]

Nature Reviews Drug Discovery, 2018
  +5 more sources

The dynamics of translation from and into Arabic in the Arab world: bibliometric analysis of the Index Translationum UNESCO database (1979–2012)

Humanities & Social Sciences Communications
This bibliometric study aims to analyze the translated literature in the Arab nations that exhibit the highest levels of dynamism spanning from 1979–2012, using the Index Translationum database.
Fawziah Ali Alshehri, Fadiah Abdullah Alshehri, Mutahar Qassem, Wafa Bedjaoui, Asma Ahmed Alfaisal   +4 more
doaj   +1 more source