Results 101 to 110 of about 7,340,134 (257)

Use of Technology in the Rehabilitation Setting: Therapy Observations, Mixed Methods Analysis, and Data Visualization

Archives of Rehabilitation Research and Clinical Translation
Objective: To analyze real-world rehabilitation technology (RT) use, with a view toward enhancing RT development and adoption. Design: A convergent, mixed-methods study using therapy observations, semistructured templates, and summative content analysis.
Courtney Celian, M/OT, Hannah Redd, PT, DPT, Kevin Smaller, BS, Partha Ryali, PhD, James L. Patton, PhD, David J. Reinkensmeyer, PhD, Miriam R. Rafferty, PT, DPT, PhD   +6 more
doaj   +1 more source

The translator’s social environments: an interdisciplinary coexistence of Translation and Sociological Studies

Traduction et Langues, 2021
Sociological approaches to translation have been developed on the theoretical basis that translation is an activity that is closely affected by social parametres.
Evanthia Saridaki
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evaluating the effectiveness of a multi-component lifestyle therapy program versus psychological therapy for managing mood disorders (HARMON-E): protocol of a randomised non-inferiority trial

BMC Psychiatry
Background Mood disorders, including unipolar and bipolar depression, contribute significantly to the global burden of disease. Psychological therapy is considered a gold standard non-pharmacological treatment for managing these conditions; however, a ...
Jessica A Davis, Madeleine L Connolly, Lauren M Young, Megan Turner, Sophie Mahoney, Dean Saunders, Tayla John, Rachel Fiddes, Marita Bryan, Michael Berk, Indee Davids, Sanna Barrand, Felice N Jacka, Greg Murray, Eileen McDonald, Mary Lou Chatterton, Catherine Kaylor-Hughes, Catherine Mihalopoulos, Alison Yung, Neil Thomas, Richard Osborne, Ravi Iyer, Denny Meyer, Lara Radovic, Tabinda Jabeen, Wolfgang Marx, Melissa O’Shea, Niamh L Mundell, Elena S George, Tetyana Rocks, Anu Ruusunen, Samantha Russell, Adrienne O’Neil, on behalf of the HARMON-E trial team   +33 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Growth of Giant Peptide Vesicles Driven by Compartmentalized Transcription-Translation Activity. [PDF]

Chemistry, 2020
Frank T, Vogele K, Dupin A, Simmel FC, Pirzer T.   +4 more
europepmc   +1 more source

Effects of weight loss through dietary intervention on pain characteristics, functional mobility, and inflammation in adults with elevated adiposity

Frontiers in Nutrition
BackgroundThe relationship between adiposity and pain is complex. Excess weight increases the risk for chronic musculoskeletal pain (CMP), driven by increased biomechanical load and low-grade systemic inflammation.
Susan J. Ward, Susan J. Ward, Alison M. Coates, Alison M. Coates, Sharayah Carter, Sharayah Carter, Katherine L. Baldock, Carolyn Berryman, Carolyn Berryman, Tasha R. Stanton, Tasha R. Stanton, Tasha R. Stanton, Catherine Yandell, Jonathan D. Buckley, Jonathan D. Buckley, Sze-Yen Tan, Geraint B. Rogers, Alison M. Hill, Alison M. Hill   +18 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source