Results 81 to 90 of about 7,340,134 (257)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity
Nature CommunicationsThere are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. The role of amyloid beta 42 (Aβ42) in these diverse chronic diseases is obscure.
Liam G. Hall +17 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Lattice score based data cleaning for phrase-based statistical machine translation [PDF]
, 2010 Statistical machine translation relies heavily on parallel corpora to train its models for translation tasks. While more and more bilingual corpora are readily available, the quality of the sentence pairs should be taken into consideration.
Way, Andy +2 more
core +2 more sources
El aprendizaje de la iniciación deportiva a través de la divulgación en AICLE
Sport TKEl presente estudio pretende enseñar a los alumnos a comunicar y una idea vinculado a la iniciación deportiva. Así, una reflexión previa les ayudará a familiarizarse con el trabajo que deben exponer ante sus compañeros.
Francisco Tomás González-Fernández +3 more
doaj +1 more source
Translation at the United Nations as Specialized Translation
JoSTrans: The Journal of Specialised Translation, 2008 Multilingualism is one of the foundations of the United Nations (UN) and translation of UN documents plays an important political and practical role in the functioning of the Organ isation. This paper argues that UN translation is a special ised area of
Deborah Cao Xingmin Zhao
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The Stem-Loop I of Senecavirus A IRES Is Essential for Cap-Independent Translation Activity and Virus Recovery. [PDF]
Viruses, 2021 Wang N +9 more
europepmc +1 more source
Acta Obstetricia et Gynecologica ScandinavicaIntroduction Physical activity (PA) during pregnancy has numerous benefits, which may be mediated via effects on the immune system. However, supportive evidence is inconsistent and is mainly from studies in high‐risk groups. We estimated the effect of PA
Poshmaal Dhar +14 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source