Results 71 to 80 of about 7,340,134 (257)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Professional translators’ self-concepts and directionality : indications from translation process research [PDF]

, 2016
Translation into a second language (also called inverse translation or L2 translation) is a widespread professional practice in many language communities.
Hunziker Heeb, Andrea
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Translation of a book of evidence and its impact on a criminal trial - A case study [PDF]

, 2012
Interpreting in a legal setting in Ireland is not subject to any regulation. Police and court interpreters are neither certified nor tested. The current study aims to analyse the impact on a criminal trial of unqualified interpreters’ assistance in the ...
Jarmolowska, Karolina
core   +1 more source

Incidence of metabolic and bariatric surgery among US adults with obesity by diabetes status: 2016–2020

BMJ Open Diabetes Research & Care
Introduction Metabolic and bariatric surgery (MBS) is an effective intervention to manage diabetes and obesity. The population-based incidence of MBS is unknown.Objective To estimate the incidence of MBS among US adults with obesity by diabetes status ...
Kai McKeever Bullard, Stephen R Benoit, Israel Hora, Fang Xu, Yiling J Cheng, Brook Belay, Christopher S Holliday, Roberto Simons-Linares   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

ANALISIS TERJEMAHAN EUFEMISME ORGAN DAN AKTIFITAS SEKSUAL DALAM NOVEL FIFTY SHADES OF GREY

Prasasti: Journal of Linguistics, 2017
This research is aimed to: (1) identify the kinds of euphemism sexual organ and sexual activity in  Fifty Shades of Grey novel, (2) identify the translation techniques used by the translator in translating sexual organ and sexual activity with euphemism,
Desi Zauhana Arifin, Djatmika Djatmika, Tri Wiratno   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Test-retest reliability of handgrip muscle function among Australian rules football athletes

Journal of Exercise Science & Fitness
Background/objective: Advancements in handgrip dynamometry provide unique opportunities to measure multiple aspects of handgrip muscle function. The aim of this study was to quantify the test-retest reliability of handgrip muscle function among athletes ...
Liam O. Mathews, Hazel R. Jaekel, Nicola D. Ridgers, Mark J. Catley, Grant R. Tomkinson   +4 more
doaj   +1 more source