Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge [PDF]
Bioinform., 2014 Motivation: Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormones is an essential question in biomedicine. Very often, however, this question cannot be addressed because it is not possible to perform experiments in ...
Kahn Rhrissorrakrai +13 more
openalex +2 more sources
10 Years of GWAS Discovery: Biology, Function, and Translation
American Journal of Human Genetics, 2017 Peter M. Visscher +6 more
openalex +2 more sources
Challenges in observing transcription–translation for bottom-up synthetic biology
QRB DiscoverySynthetic biology aims to create a viable synthetic cell. However, to achieve this goal, it is essential first to gain a profound understanding of the cellular systems used to build that cell, how to reconstitute those systems in the compartments, and ...
Vadim G. Bogatyr, Gijs J. L. Wuite
doaj +2 more sources
CXCL8 in Tumor Biology and Its Implications for Clinical Translation
Frontiers in Molecular Biosciences, 2022 The chemokine CXCL8 has been found to play an important role in tumor progression in recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its receptors (CXCR1/2), and plays dual pro-tumorigenic roles in the tumor ...
Xingyu Xiong +7 more
semanticscholar +1 more source
Malignant Peripheral Nerve Sheath Tumor: Models, Biology, and Translation
Oncogene, 2022 Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients with Neurofibromatosis Type 1.
B. Somatilaka +3 more
semanticscholar +1 more source
Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
Journal of Biomedical Science, 2022 The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis that demands the timely creation of new therapeutics and viral detection.
Yu-Chyi Hwang +8 more
doaj +1 more source
Journal of Biomedical Science, 2022 Background The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics.
Shih-Han Ko +9 more
doaj +1 more source
UPF1: From mRNA Surveillance to Protein Quality Control
Biomedicines, 2021 Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant ...
Hyun Jung Hwang +2 more
doaj +1 more source
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
Nature Communications, 2022 LC3/ATG8 plays an essential role in autophagy. Here the authors show that LC3B exhibits RNA-binding ability and induces rapid degradation of target mRNAs via autophagic activation, highlighting the interplay between autophagy and RNA biology.
Hyun Jung Hwang +5 more
doaj +1 more source
Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]
, 2020 Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E. +6 more
core +1 more source