Results 1 to 10 of about 2,536,009 (216)

10 Years of GWAS Discovery: Biology, Function, and Translation [PDF]

American Journal of Human Genetics, 2017
Peter M. Visscher, Naomi R. Wray, Qian Zhang, Pamela Sklar, Mark I. McCarthy, Matthew A. Brown, Jian Yang   +6 more
openalex   +2 more sources

Challenges in observing transcription–translation for bottom-up synthetic biology

QRB Discovery
Synthetic biology aims to create a viable synthetic cell. However, to achieve this goal, it is essential first to gain a profound understanding of the cellular systems used to build that cell, how to reconstitute those systems in the compartments, and ...
Vadim Bogatyr, Gijs J. L. Wuite
openalex   +3 more sources

Haploidentical hematopoietic transplantation for the cure of leukemia: from its biology to clinical translation [PDF]

Blood, 2016
Antonella Mancusi, Loredana Ruggeri, Andrea Velardi   +2 more
openalex   +2 more sources

Malignant Peripheral Nerve Sheath Tumor: Models, Biology, and Translation

Oncogene, 2022
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients with Neurofibromatosis Type 1.
B. Somatilaka, Aliaa Sadek, R. McKay, L. Le   +3 more
semanticscholar   +1 more source

CXCL8 in Tumor Biology and Its Implications for Clinical Translation

Frontiers in Molecular Biosciences, 2022
The chemokine CXCL8 has been found to play an important role in tumor progression in recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its receptors (CXCR1/2), and plays dual pro-tumorigenic roles in the tumor ...
Xingyu Xiong, Xinyang Liao, S. Qiu, Hang Xu, Shiyu Zhang, Sheng Wang, J. Ai, L. Yang   +7 more
semanticscholar   +1 more source

Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

Journal of Biomedical Science, 2022
The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis that demands the timely creation of new therapeutics and viral detection.
Yu-Chyi Hwang, Ruei-Min Lu, Shih-Chieh Su, Pao-Yin Chiang, Shih-Han Ko, Feng-Yi Ke, Kang-Hao Liang, Tzung-Yang Hsieh, Han-Chung Wu   +8 more
doaj   +1 more source

Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants

Journal of Biomedical Science, 2022
Background The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics.
Shih-Han Ko, Wan-Yu Chen, Shih-Chieh Su, Hsiu-Ting Lin, Feng-Yi Ke, Kang-Hao Liang, Fu-Fei Hsu, Monika Kumari, Chi-Yu Fu, Han-Chung Wu   +9 more
doaj   +1 more source

UPF1: From mRNA Surveillance to Protein Quality Control

Biomedicines, 2021
Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant ...
Hyun Jung Hwang, Yeonkyoung Park, Yoon Ki Kim   +2 more
doaj   +1 more source

LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy

Nature Communications, 2022
LC3/ATG8 plays an essential role in autophagy. Here the authors show that LC3B exhibits RNA-binding ability and induces rapid degradation of target mRNAs via autophagic activation, highlighting the interplay between autophagy and RNA biology.
Hyun Jung Hwang, Hongseok Ha, Ban Seok Lee, Bong Heon Kim, Hyun Kyu Song, Yoon Ki Kim   +5 more
doaj   +1 more source

Antibody cocktail effective against variants of SARS-CoV-2

Journal of Biomedical Science, 2021
Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA virus with a high mutation rate.
Kang-Hao Liang, Pao-Yin Chiang, Shih-Han Ko, Yu-Chi Chou, Ruei-Min Lu, Hsiu-Ting Lin, Wan-Yu Chen, Yi-Ling Lin, Mi-Hua Tao, Jia-Tsrong Jan, Han-Chung Wu   +10 more
doaj   +1 more source