Results 1 to 10 of about 3,070,291 (402)

In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology

Cell Reports, 2017
Summary: Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism often result in neurodegenerative conditions, with increasing evidence suggesting that translation defects can contribute to disease.
Paola Bernabò, Toma Tebaldi, Ewout J.N. Groen, Fiona M. Lane, Elena Perenthaler, Francesca Mattedi, Helen J. Newbery, Haiyan Zhou, Paola Zuccotti, Valentina Potrich, Hannah K. Shorrock, Francesco Muntoni, Alessandro Quattrone, Thomas H. Gillingwater, Gabriella Viero   +14 more
doaj   +1 more source

New Perspectives on Reverse Translation: Brief History and Updates

Universitas Scientiarum, 2023
Since the 1950s, reverse translation has been an enigmatic part of Crick’s central dogma of molecular biology. It might be described as the possibility to back-translate information from proteins to nucleic acids (or codons).
Adhityo Wicaksono, Viol Dhea Kharisma, Arli Aditya Parikesit   +2 more
doaj   +1 more source

Chemical Allergy: Translating Biology into Hazard Characterization [PDF]

Toxicological Sciences, 2010
The induction by chemicals of allergic sensitization and allergic disease is an important and challenging branch of toxicology. Skin sensitization resulting in allergic contact dermatitis represents the most common manifestation of immunotoxicity in humans, and many hundreds of chemicals have been implicated as skin sensitizers.
Kimber, Ian, Basketter, David A., Gerberick, G. Frank, Ryan, Cindy A., Dearman, Rebecca J.   +4 more
openaire   +2 more sources

Building the UK's industrial base in engineering biology

Engineering Biology, 2021
The paper describes the strategy and components that have been put in place to build the UK's research and industrial base in Engineering Biology. The initial section of the paper provides a brief historical overview of the development of the field in ...
Richard I. Kitney
doaj   +1 more source

Positional proteomics reveals differences in N-terminal proteoform stability [PDF]

, 2016
To understand the impact of alternative translation initiation on a proteome, we performed a proteome-wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes.
Brown JL, Daria Gawron, Elvis Ndah, Kris Gevaert, Petra Van Damme   +4 more
core   +2 more sources

Correction: Wang et al. A VLP-Based Vaccine Displaying HBHA and MTP Antigens of Mycobacterium tuberculosis Induces Potentially Protective Immune Responses in M. tuberculosis H37Ra Infected Mice. Vaccines 2023, 11, 941

Vaccines, 2023
Concerns were brought to the attention of the journal’s editorial office after the paper was published [...]
Juan Wang, Tao Xie, Inayat Ullah, Youjun Mi, Xiaoping Li, Yang Gong, Pu He, Yuqi Liu, Fei Li, Jixi Li, Zengjun Lu, Bingdong Zhu   +11 more
doaj   +1 more source

Interaction of yeast eIF4G with spliceosome components Implications in pre-mRNA processing events [PDF]

, 2009
International audienceAs evidenced from mammalian cells the eukaryotic translation initiation factor eIF4G has a putative role in nuclear RNA metabolism. Here we investigate whether this role is conserved in the yeast Saccharomyces cerevisiae.
Barrass, J. David, Beggs, Jean D., Fromont-Racine, Micheline, Jacquier, Alain, Kafasla, Panagiota, Lewis, Joe, Thompson, Elizabeth   +6 more
core   +2 more sources

Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

Nature Communications, 2017
Misfolded polypeptide aggregates are actively transported to aggresomes, where they are degraded through aggrephagy. Here the authors show that these aggregates are selectively recognized by the CTIF–eEF1A1–DCTN1 (CED) complex and transported to ...
Joori Park, Yeonkyoung Park, Incheol Ryu, Mi-Hyun Choi, Hyo Jin Lee, Nara Oh, Kyutae Kim, Kyoung Mi Kim, Junho Choe, Cheolju Lee, Ja-Hyun Baik, Yoon Ki Kim   +11 more
doaj   +1 more source

Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D

Journal of Experimental & Clinical Cancer Research, 2018
Background Drugs that inhibit the MEK/ERK pathway have therapeutic benefit in bladder cancer treatment but responses vary with patients, for reasons that are still not very clear.
Zhe Qiang, Zong-yuan Zhou, Ting Peng, Pu-zi Jiang, Nan Shi, Emmanuel Mfotie Njoya, Bahtigul Azimova, Wan-li Liu, Wei-hua Chen, Guo-lin Zhang, Fei Wang   +10 more
doaj   +1 more source

A remark on the frequent hypercyclicity criterion for weighted composition semigroups and an application to the linear von Foerster-Lasota equation

, 2014
We generalize a result for the translation $C_0$-semigroup on $L^p(\R_+,\mu)$ about the equivalence of being chaotic and satisfying the Frequent Hypercyclicity criterion due to Mangino and Peris to certain weighted composition $C_0$-semigroups. Such $C_0$
Kalmes, Thomas
core   +1 more source