Results 1 to 10 of about 2,436,936 (150)
CXCL8 in Tumor Biology and Its Implications for Clinical Translation
Frontiers in Molecular Biosciences, 2022 The chemokine CXCL8 has been found to play an important role in tumor progression in recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its receptors (CXCR1/2), and plays dual pro-tumorigenic roles in the tumor ...
Xingyu Xiong +7 more
semanticscholar +1 more source
Malignant Peripheral Nerve Sheath Tumor: Models, Biology, and Translation
Oncogene, 2022 Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients with Neurofibromatosis Type 1.
B. Somatilaka +3 more
semanticscholar +1 more source
Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
Journal of Biomedical Science, 2022 The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis that demands the timely creation of new therapeutics and viral detection.
Yu-Chyi Hwang +8 more
doaj +1 more source
Journal of Biomedical Science, 2022 Background The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics.
Shih-Han Ko +9 more
doaj +1 more source
UPF1: From mRNA Surveillance to Protein Quality Control
Biomedicines, 2021 Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant ...
Hyun Jung Hwang +2 more
doaj +1 more source
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
Nature Communications, 2022 LC3/ATG8 plays an essential role in autophagy. Here the authors show that LC3B exhibits RNA-binding ability and induces rapid degradation of target mRNAs via autophagic activation, highlighting the interplay between autophagy and RNA biology.
Hyun Jung Hwang +5 more
doaj +1 more source
Antibody cocktail effective against variants of SARS-CoV-2
Journal of Biomedical Science, 2021 Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA virus with a high mutation rate.
Kang-Hao Liang +10 more
doaj +1 more source
Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
Nature Communications, 2020 Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated ...
Yeonkyoung Park +7 more
doaj +1 more source
Journal of Biomedical Science, 2023 mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune ...
Yu-Shiuan Wang +6 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of
Ragunathan Bava Ganesh +1 more
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