Results 11 to 20 of about 3,070,291 (402)
Hijacking Translation Initiation for Synthetic Biology
ChemBioChem, 2020 AbstractGenetic code expansion (GCE) has revolutionized the field of protein chemistry. Over the past several decades more than 150 different noncanonical amino acids (ncAAs) have been co‐translationally installed into proteins within various host organisms.
Jeffery M. Tharp +3 more
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The expanding incretin universe: from basic biology to clinical translation [PDF]
Diabetologia, 2023 Daniel J. Drucker, Jens J. Holst
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Repurposing the translation apparatus for synthetic biology [PDF]
Current Opinion in Chemical Biology, 2015 The translation system (the ribosome and associated factors) is the cell's factory for protein synthesis. The extraordinary catalytic capacity of the protein synthesis machinery has driven extensive efforts to harness it for novel functions. For example, pioneering efforts have demonstrated that it is possible to genetically encode more than the 20 ...
Des Soye, Benjamin J +3 more
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Stromal biology and therapy in pancreatic cancer: ready for clinical translation? [PDF]
Gut, 2018 Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote tumour progression, metastasis niche formation and therapeutic resistance ...
Albrecht Neeße +7 more
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Malignant Peripheral Nerve Sheath Tumor: Models, Biology, and Translation
Oncogene, 2022 Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients with Neurofibromatosis Type 1.
B. Somatilaka +3 more
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CXCL8 in Tumor Biology and Its Implications for Clinical Translation
Frontiers in Molecular Biosciences, 2022 The chemokine CXCL8 has been found to play an important role in tumor progression in recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its receptors (CXCR1/2), and plays dual pro-tumorigenic roles in the tumor ...
Xingyu Xiong +7 more
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Translational synthetic biology [PDF]
Systems and Synthetic Biology, 2015 Synthetic biology is a recent scientific approach towards engineering biological systems from both pre-existing and novel parts. The aim is to introduce computational aided design approach in biology leading to rapid delivery of useful applications. Though the term reprogramming has been frequently used in the synthetic biology community, currently the
Mamta, Singh, Anuradha, Vaidya
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Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
Journal of Biomedical Science, 2022 The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis that demands the timely creation of new therapeutics and viral detection.
Yu-Chyi Hwang +8 more
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Journal of Biomedical Science, 2022 Background The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics.
Shih-Han Ko +9 more
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UPF1: From mRNA Surveillance to Protein Quality Control
Biomedicines, 2021 Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant ...
Hyun Jung Hwang +2 more
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