Results 11 to 20 of about 2,536,108 (315)
Heliyon, 2023 The COVID-19 pandemic continues to threaten human health worldwide as new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge. Currently, the predominant circulating strains around the world are Omicron variants, which can
Ruei-Min Lu +11 more
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Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
Nature Communications, 2020 Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated ...
Yeonkyoung Park +7 more
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Frontiers in Bioengineering and Biotechnology, 2022 Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of
Ragunathan Bava Ganesh +1 more
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Genes & Development, 2020 In this review, Kim et al. discuss the importance of PARP family members and ADPRylation in gene regulation, mRNA processing, and protein abundance.
Dae-Seok Kim +3 more
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Journal of Biomedical Science, 2023 mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune ...
Yu-Shiuan Wang +6 more
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eIF2B-capturing viral protein NSs suppresses the integrated stress response
Nature Communications, 2021 Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates
Kazuhiro Kashiwagi +10 more
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Proximity-Based Modalities for Biology and Medicine
ACS Central Science, 2023 Molecular proximity orchestrates biological function, and blocking existing proximities is an established therapeutic strategy. By contrast, strengthening or creating neoproximity with chemistry enables modulation of biological processes with high ...
Xingui Liu, A. Ciulli
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The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
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Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition
Scientific Reports, 2021 The Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults.
Yong Wah Tan +5 more
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Journal of Biomedical Science, 2022 The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed vaccines, diagnostic tools and therapeutics ...
Monika Kumari +16 more
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