Results 11 to 20 of about 925,579 (306)

Biochemistry of Aminoacyl tRNA Synthetase and tRNAs and Their Engineering for Cell-Free and Synthetic Cell Applications

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of
Ragunathan Bava Ganesh   +1 more
doaj   +1 more source

eIF2B-capturing viral protein NSs suppresses the integrated stress response

open access: yesNature Communications, 2021
Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates
Kazuhiro Kashiwagi   +10 more
doaj   +1 more source

The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans [PDF]

open access: yes, 2011
Despite the importance of microRNAs (miRNAs) in gene regulation, it is unclear how the miRNA-Argonaute complex-or miRNA-induced silencing complex (miRISC)-can regulate the translation of their targets in such diverse ways.
Bajan, Sarah   +7 more
core   +3 more sources

The emerging role of RNA modifications in the regulation of mRNA stability

open access: yesExperimental and Molecular Medicine, 2020
Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
doaj   +1 more source

Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition

open access: yesScientific Reports, 2021
The Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults.
Yong Wah Tan   +5 more
doaj   +1 more source

Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. [PDF]

open access: yes, 2017
Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery.
Gimzewski, James K   +7 more
core   +2 more sources

A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

open access: yesJournal of Biomedical Science, 2022
The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed vaccines, diagnostic tools and therapeutics ...
Monika Kumari   +16 more
doaj   +1 more source

Problems of specialist translations on examples of texts from domains like biology, biotechnology and medicine [PDF]

open access: yes, 2007
This article deals with the analysis of problems in translation of EU directives from English into Polish. The examples were taken from three directives regulating medicine, biology and biotechnology-related matters.
Kłos, Patrycja   +2 more
core   +2 more sources

Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. [PDF]

open access: yes, 2013
The initiation of protein synthesis plays an essential regulatory role in human biology. At the center of the initiation pathway, the 13-subunit eukaryotic translation initiation factor 3 (eIF3) controls access of other initiation factors and mRNA to the
Arias-Palomo, Ernesto   +6 more
core   +1 more source

YAMAT-seq: an efficient method for high-throughput sequencing of mature transfer RNAs. [PDF]

open access: yes, 2017
Besides translation, transfer RNAs (tRNAs) play many non-canonical roles in various biological pathways and exhibit highly variable expression profiles.
Honda, Shozo   +5 more
core   +2 more sources

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