Results 11 to 20 of about 2,436,936 (150)
Genes & Development, 2020 In this review, Kim et al. discuss the importance of PARP family members and ADPRylation in gene regulation, mRNA processing, and protein abundance.
Dae-Seok Kim +3 more
semanticscholar +1 more source
eIF2B-capturing viral protein NSs suppresses the integrated stress response
Nature Communications, 2021 Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates
Kazuhiro Kashiwagi +10 more
doaj +1 more source
Hijacking Translation Initiation for Synthetic Biology
ChemBioChem, 2020 Genetic code expansion (GCE) has revolutionized the field of protein chemistry. Over the past several decades more than 150 different noncanonical amino acids (ncAAs) have been co‐translationally installed into proteins within various host organisms. The
Jeffery M. Tharp +3 more
semanticscholar +1 more source
Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition
Scientific Reports, 2021 The Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults.
Yong Wah Tan +5 more
doaj +1 more source
Proximity-Based Modalities for Biology and Medicine
ACS Central Science, 2023 Molecular proximity orchestrates biological function, and blocking existing proximities is an established therapeutic strategy. By contrast, strengthening or creating neoproximity with chemistry enables modulation of biological processes with high ...
Xingui Liu, A. Ciulli
semanticscholar +1 more source
The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
doaj +1 more source
Journal of Biomedical Science, 2022 The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed vaccines, diagnostic tools and therapeutics ...
Monika Kumari +16 more
doaj +1 more source
Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
Gut, 2018 Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote tumour progression, metastasis niche formation and therapeutic resistance ...
A. Neesse +7 more
semanticscholar +1 more source
Translation initiation consistency between in vivo and in vitro bacterial protein expression systems
Frontiers in Bioengineering and Biotechnology, 2023 Strict on-demand control of protein synthesis is a crucial aspect of synthetic biology. The 5′-terminal untranslated region (5′-UTR) is an essential bacterial genetic element that can be designed for the regulation of translation initiation.
Jiaojiao Li +10 more
doaj +1 more source
Stem cell research & therapeutics, 2017 Adipose/fat tissue provides an abundant source of stromal vascular fraction (SVF) cells for immediate administration and can also give rise to a substantial number of cultured, multipotent adipose-derived stromal cells (ADSCs).
Pablo Bora, A. Majumdar
semanticscholar +1 more source