Results 61 to 70 of about 8,994,214 (249)
Some Notes on Left-Dislocation in the Homilies of Wulfstan
LanguagesIn this paper, I show how pragmatics and syntax are interconnected in Old English by examining the left-dislocation system in Wulfstan’s homilies. Syntactically, this article argues that left-dislocation fits in nicely with the system found in other Old ...
Artur Bartnik
doaj +1 more source
Chronotopos, 2019 In the four years of Finland’s Continuation War against the USSR, Finnish troops captured 67,000 Soviet prisoners-of-war who were handled behind lines in an extended network of POW formations.
Pekka Kujamäki, Päivi Pasanen
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The ethical dimension of translation revision : an empirical study [PDF]
, 2007 This paper investigates translation revision using think-aloud protocols. Ten professional translators were asked to think aloud while revising three draft translations.
Künzli, Alexander
core +1 more source
TranscUlturAl, 2015 Anita Desai’s latest story collection, The Artist of Disappearance, includes a novella titled “Translator, Translated.” In it, a naïve young woman begs a former classmate, who now runs a publishing house, to give her the chance to render a beloved Oriya ...
Valerie Henitiuk
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Translation as human-computer interaction [PDF]
, 2012 This paper seeks to characterise translation as a form of human-computer interaction. The evolution of translator-computer interaction is explored and the challenges and benefits are enunciated.
O'Brien, Sharon, O\u27Brien, Sharon
core +4 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source