Results 31 to 40 of about 97,136 (259)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Practices, Education and Technology in Audiovisual Translation [PDF]
This book explores the intersections of education and technology in audiovisual translation, unpacking the evolution of AVT ecosystems and looking ahead to future directions for the role of technology in the translation industry and higher education. The
Bolaños García-Escribano, Alejandro
core +2 more sources
Learned industriousness as a translational mechanism in anorexia nervosa
Nature Reviews Psychology, 2021 Researchers have long grappled to understand the persistence of behaviors that are non-hedonic and, ostensibly, aversive. At times, such behaviors are taken to excess in the form of psychopathology. Anorexia nervosa characterizes a prototype of a disorder in which behaviors that most people find unpleasant (e.g., restrictive eating, excessive exercise)
Ann Frances Haynos +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Translation strategies in English to Persian
, 2020 One implication of the results is for translators in the sense that they become aware of the translation strategies used in the Persian translation of the English novel 'Whatever after, Fairest of all' written by 'Sarah Mlynowski'. To be more particular,
Mikoladze, D. L.
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Seeding statistical machine translation with translation memory output through tree-based structural alignment [PDF]
, 2010 With the steadily increasing demand for high-quality translation, the localisation industry is constantly searching for technologies that would increase translator throughput, with the current focus on the use of high-quality Statistical Machine ...
Zhechev, Ventsislav, van Genabith, Josef
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Ergonomics in translation work
Putting the human actor in the centre of an industrial process began with the emergence of the field known as ergonomics. Nowadays, the translation industry refers to the importance of the ‘expert in the loop’ to highlight the limitations of technology ...
Hunziker Heeb, Andrea +1 more
core +1 more source