Results 51 to 60 of about 97,136 (259)
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Teaching machine translation and translation technology: a contrastive study
, 2001 The Machine Translation course at Dublin City University is taught to undergraduate students in Applied Computational Linguistics, while Computer-Assisted Translation is taught on two translator-training programmes, one undergraduate and one ...
Way, Andy, Kenny, Dorothy
core
Post-editing machine translated text in a commercial setting: Observation and statistical analysis [PDF]
, 2010 Machine translation systems, when they are used in a commercial context for publishing purposes, are usually used in combination with human post-editing.
Tatsumi, Midori
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Translating Creative Texts through Machine Translation: Deepl vs. Google Translate
Together with advancements in technology, there is an ongoing change in Translation Studies as more and more technological tools are being developed and implemented.
Sırkıntı, Hulisi Alp +1 more
core +1 more source
Adapting machine translation education to the neural era : a case study of MT quality assessment
, 2023 The use of automatic evaluation metrics to is well established in the translation industry. Whereas it is relatively easy to cover the word- and character-based metrics in an MT course, it is less obvious to integrate the newer neural metrics.
Vanroy, BramUGent0001615296528020026585439747705382060000-0002-4622-8364C50B0474-7EE0-11E7-B38D-2BA4AD28A064 +18 more
core
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source