Results 61 to 70 of about 314,589 (303)

The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection [PDF]

, 2011
As obligate intracellular parasites, viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two
McMahon, Robert
core  

Synaptic Plasticity and Translation Initiation [PDF]

Learning & Memory, 2004
It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA.
Eric, Klann, Marcia D, Antion, Jessica L, Banko, Lingfei, Hou   +3 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Comprehensive profiling of translation initiation in influenza virus infected cells.

PLoS Pathogens, 2019
Translation can initiate at alternate, non-canonical start codons in response to stressful stimuli in mammalian cells. Recent studies suggest that viral infection and anti-viral responses alter sites of translation initiation, and in some cases, lead to ...
Heather M Machkovech, Jesse D Bloom, Arvind R Subramaniam   +2 more
doaj   +1 more source

Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB.

PLoS ONE, 2013
Protein synthesis is mainly regulated at the initiation step, allowing the fast, reversible and spatial control of gene expression. Initiation of protein synthesis requires at least 13 translation initiation factors to assemble the 80S ribosomal ...
Giuseppe Fiume, Annalisa Rossi, Annamaria de Laurentiis, Cristina Falcone, Antonio Pisano, Eleonora Vecchio, Marilena Pontoriero, Iris Scala, Annarita Scialdone, Francesca Fasanella Masci, Selena Mimmi, Camillo Palmieri, Giuseppe Scala, Ileana Quinto   +13 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Role of Translation Initiation Regulation in Haematopoiesis [PDF]

Comparative and Functional Genomics, 2012
Organisation of RNAs into functional subgroups that are translated in response to extrinsic and intrinsic factors underlines a relatively unexplored gene expression modulation that drives cell fate in the same manner as regulation of the transcriptome by transcription factors.
Godfrey Grech, Marieke von Lindern
openaire   +3 more sources

Recent Advances in Archaeal Translation Initiation

Frontiers in Microbiology, 2020
Translation initiation (TI) allows accurate selection of the initiation codon on a messenger RNA (mRNA) and defines the reading frame. In all domains of life, translation initiation generally occurs within a macromolecular complex made up of the small ...
Emmanuelle Schmitt, Pierre-Damien Coureux, Ramy Kazan, Gabrielle Bourgeois, Christine Lazennec-Schurdevin, Yves Mechulam   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview [PDF]

, 2012
Translation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein.
von der Haar, Tobias, Tobias von der Haar   +1 more
core   +1 more source