Results 61 to 70 of about 1,545,528 (302)
, 2012 ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Hopfner, Karl-Peter
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Comprehensive profiling of translation initiation in influenza virus infected cells.
PLoS Pathogens, 2019 Translation can initiate at alternate, non-canonical start codons in response to stressful stimuli in mammalian cells. Recent studies suggest that viral infection and anti-viral responses alter sites of translation initiation, and in some cases, lead to ...
Heather M Machkovech +2 more
doaj +1 more source
Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB.
PLoS ONE, 2013 Protein synthesis is mainly regulated at the initiation step, allowing the fast, reversible and spatial control of gene expression. Initiation of protein synthesis requires at least 13 translation initiation factors to assemble the 80S ribosomal ...
Giuseppe Fiume +13 more
doaj +1 more source
A Deeper Look into Translation Initiation [PDF]
Cell, 2014 Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation intermediates.
openaire +3 more sources
The Role of Translation Initiation Regulation in Haematopoiesis [PDF]
Comparative and Functional Genomics, 2012 Organisation of RNAs into functional subgroups that are translated in response to extrinsic and intrinsic factors underlines a relatively unexplored gene expression modulation that drives cell fate in the same manner as regulation of the transcriptome by transcription factors.
Godfrey Grech, Marieke von Lindern
openaire +3 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
eLifeTranslation initiation in eukaryotes requires a 40 S ribosome loaded with initiator tRNA which scans for an initiation codon. The initiator tRNA is usually recruited to the ribosome as part of a ternary complex composed of initiator tRNA, eIF2, and GTP ...
Mykola Roiuk +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor
Life Science AllianceThis work identifies missense mutations in the translation initiation factor EIF4G2 gene in cancer, showing loss-of-function effects on binding to interacting proteins and translational activity.
Sara Meril +7 more
doaj +1 more source