Results 51 to 60 of about 314,589 (303)

The Insertion Domain of Mti2 Facilitates the Association of Mitochondrial Initiation Factors with Mitoribosomes in Schizosaccharomyces pombe

Biomolecules
Translation initiation in mitochondria involves unique mechanisms distinct from those in the cytosol or in bacteria. The Schizosaccharomyces pombe mitochondrial translation initiation factor 2 (Mti2) is the ortholog of human MTIF2, which plays a vital ...
Ying Luo, Jürg Bähler, Ying Huang
doaj   +1 more source

Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms

Exploration of Targeted Anti-tumor Therapy, 2020
Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins.
Joe Taylor, Alison M Yeomans, Graham Packham   +2 more
doaj   +1 more source

Synonymous codon usage regulates translation initiation

Cell Reports, 2023
Summary: Nonoptimal synonymous codons repress gene expression, but the underlying mechanisms are poorly understood. We and others have previously shown that nonoptimal codons slow translation elongation speeds and thereby trigger messenger RNA (mRNA ...
Chloe L. Barrington, Gabriel Galindo, Amanda L. Koch, Emma R. Horton, Evan J. Morrison, Samantha Tisa, Timothy J. Stasevich, Olivia S. Rissland   +7 more
doaj   +1 more source

Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic limb‐threatening ischemia (CLTI) is a severe form of lower‐extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low‐density lipoprotein (LDL) adsorption device with potential rheological and anti‐inflammatory ...
Kunihiro Ishioka, Takayasu Ohtake, Kei Ohmori, Chika Shibuya, Tomoki Tsukahara, Mizuki Yamano, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Yusuke Tsukamoto, Hidekazu Moriya, Sumi Hidaka, Shuzo Kobayashi   +12 more
wiley   +1 more source

Specialized Yeast Ribosomes: A Customized Tool for Selective mRNA Translation [PDF]

, 2013
Evidence is now accumulating that sub-populations of ribosomes - so-called specialized ribosomes - can favour the translation of subsets of mRNAs. Here we use a large collection of diploid yeast strains, each deficient in one or other copy of the set of ...
Klausegger, Alfred, Brandl Clemens, Lore Breitenbach-Koller, Clemens Br, Bjoern Wimmer (431586), Mick F, Wimmer, Bjoern, Johann W. Bauer (431583), Manuela Weber, Clemens Brandl, Tuite Mick F., Breitenbach-Koller, Hannelore, Klausegger Alfred, Manuela Weber (431587), Johann W. Bauer, Bauer Johann W., Breitenbach-Koller, Lore, Haubenreisser Olaf, Preiss, Thomas, Breitenbach-Koller Lore, Wimmer Bjoern, Helmut Hintner, Michael Breitenbach, Olaf Haubenreisser (431585), Hintner Helmut, Breitenbach, Michael, Mick F Tuite, Alfred Klausegger, Karl Thomas, Weber Manuela, Karl, Thomas, Hintner, Helmut, Bjoern Wimmer, Haar, Thomas Von der, Haubenreisser, Olaf, von der Haar Tobias, Clemens Brandl (431584), Bauer, Johann W., Johann W Bauer, Breitenbach Michael, Thomas Karl, Mick F. Tuite (266570), Lore Breitenbach-Koller (431591), Michael Breitenbach (46789), Bauer, Johann, Tuite, Mick F., von der Haar, Tobias, Olaf Haubenreisser, Helmut Hintner (431590), Brandl, Clemens, Tobias von der Haar, Tobias von der Haar (80575), Alfred Klausegger (431589), Thomas Karl (431588), Weber, Manuela   +54 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Experimental characterization of Cis-acting elements important for translation and transcription in Halophilic Archaea

, 2007
Summary The basal transcription apparatus of archaea is well characterized. However, much less is known about the mechanisms of transcription termination and translation initation.
Jörg Soppa, Oliver Hering, Brenneis, Mariam, Mariam Brenneis, Soppa, Jörg (Prof. Dr.), Brenneis Mariam, Hering, Oliver, Lange, Christian, Christian Lange, Hering Oliver, Soppa Jörg, Lange Christian   +11 more
core   +1 more source

A Deeper Look into Translation Initiation [PDF]

Cell, 2014
Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation intermediates.
openaire   +3 more sources

The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids

Pathogens, 2017
Trypanosomatid protozoa are unusual eukaryotes that are well known for having unusual ways of controlling their gene expression. The lack of a refined mode of transcriptional control in these organisms is compensated by several post-transcriptional ...
Eden R. Freire, Nancy R. Sturm, David A. Campbell, Osvaldo P. de Melo Neto   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source