Results 31 to 40 of about 1,545,528 (302)

mTOR, translation initiation and cancer [PDF]

Oncogene, 2006
Control of mRNA translation plays a fundamental role in many aspects of cell metabolism. It constitutes a critical step in the control of gene expression, and consequently cell growth, proliferation and differentiation. Translation is regulated in response to nutrient availability, hormones, mitogenic and growth factor stimulation and is coupled with ...
Mamane, Y, Petroulakis, E, Lebacquer, O, Sonenberg, N   +3 more
openaire   +4 more sources

A var gene upstream element controls protein synthesis at the level of translation initiation in Plasmodium falciparum [PDF]

, 2013
Clonally variant protein expression in the malaria parasite Plasmodium falciparum generates phenotypic variability and allows isogenic populations to adapt to environmental changes encountered during blood stage infection.
Nicolas M B Brancucci, Kathrin Witmer, Kathrin Witmer (252635), Brancucci, Nicolas M. B., Schmid, Christoph, Christoph Schmid (44586), Till S. Voss (252644), Nicolas M. B. Brancucci (579187), Till S Voss, Witmer, Kathrin, Voss, Till S., Nicolas M. B. Brancucci, Till S. Voss, Christoph Schmid   +13 more
core   +1 more source

Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]

, 2010
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
Enrico N. De Toni, Jennifer Altomonte, Roland M Schmid, Schneider, Günter, Schmid, Roland M., Rizzani Antonia, Thasler Wolfgang E., Ebert Oliver, Thasler, Wolfgang E., Schmid Roland M., Marozin, Sabrina, De Toni, Enrico N., Kato, Nobuyuki, Marozin Sabrina, Wolfgang E Thasler, Wolfgang E. Thasler, Enrico N De Toni, Altomonte, Jennifer, Alexandra Junger, De Toni Enrico N., Altomonte Jennifer, Ebert, Oliver, Günter Schneider, Oliver Ebert, Sabrina Marozin, Junger Alexandra, Kato Nobuyuki, Roland M. Schmid, Junger, Alexandra, Schneider Günter, Nobuyuki Kato, Rizzani, Antonia, Antonia Rizzani   +32 more
core   +2 more sources

Local absence of secondary structure permits translation of mRNAs that lack ribosome-binding sites. [PDF]

PLoS Genetics, 2011
The initiation of translation is a fundamental and highly regulated process in gene expression. Translation initiation in prokaryotic systems usually requires interaction between the ribosome and an mRNA sequence upstream of the initiation codon, the so ...
Lars B Scharff, Liam Childs, Dirk Walther, Ralph Bock   +3 more
doaj   +1 more source

Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism [PDF]

, 2014
Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons.
Dyer, Nigel P., Croft, Wayne D., Gould, Phillip S., Easton, A. J. (Andrew J.), Ott, Sascha   +4 more
core   +1 more source

The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection [PDF]

, 2011
As obligate intracellular parasites, viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two
McMahon, Robert
core   +2 more sources

Noncanonical Translation Initiation in Eukaryotes [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
The vast majority of eukaryotic messenger RNAs (mRNAs) initiate translation through a canonical, cap-dependent mechanism requiring a free 5' end and 5' cap and several initiation factors to form a translationally active ribosome. Stresses such as hypoxia, apoptosis, starvation, and viral infection down-regulate cap-dependent translation during which ...
Thaddaeus, Kwan, Sunnie R, Thompson
openaire   +2 more sources

Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail [PDF]

, 2015
A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms
Struthers, M, Tuplin, AK, Tuplin, Andrew, Bentley, K, Struthers, Madeleine, Cook, J, Cook, Jonathan, Evans, DJ, Evans, David J., Struthers, Madeline, Bentley, Kirsten, Cook, Jonathan P.   +11 more
core   +1 more source

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Proud, C., Taylor, Peter M., Liu, R., Iadevaia, Valentina, Averous, Julien, Liu, R, Proud, Christopher G., Proud, CG, Taylor, P., Zhang, Z., Taylor, PM, Zhang, Z, Liu, Rui, Iadevaia, V, Zhang, Ze, Averous, J., Averous, J, Iadevaia, V.   +17 more
core   +1 more source

Comparison of computational methods for identifying translation initiation sites in EST data

BMC Bioinformatics, 2004
Background Expressed Sequence Tag (EST) sequences are generally single-strand, single-pass sequences, only 200–600 nucleotides long, contain errors resulting in frame shifts, and represent different parts of their parent cDNA.
Ellis Lynda BM, Fahrenkrug Scott C, Nadershahi Afshin   +2 more
doaj   +1 more source