Results 21 to 30 of about 1,605,540 (300)
Leveraging genome-wide datasets to quantify the functional role of the anti-Shine–Dalgarno sequence in regulating translation efficiency [PDF]
Open Biology, 2017 Studies dating back to the 1970s established that sequence complementarity between the anti-Shine–Dalgarno (aSD) sequence on prokaryotic ribosomes and the 5′ untranslated region of mRNAs helps to facilitate translation initiation. The optimal location of
Adam J. Hockenberry +3 more
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Zdorovʹe Rebenka, 2022 The scientific review considers the mechanisms of action of cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during the initiation and post-initiation period of translation.
A.E. Abaturov, V.L. Babуch
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Translation initiation of viral mRNAs [PDF]
Reviews in Medical Virology, 2010 AbstractViruses depend on cells for their replication but have evolved mechanisms to achieve this in an efficient and, in some instances, a cell‐type‐specific manner. The expression of viral proteins is frequently subject to translational control. The dominant target of such control is the initiation step of protein synthesis.
Lopez-Lastra, Marcelo +5 more
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PLoS ONE, 2022 A number of neurologic diseases associated with expanded nucleotide repeats, including an inherited form of amyotrophic lateral sclerosis, have an unconventional form of translation called repeat-associated non-AUG (RAN) translation.
Alec C Gleason +4 more
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The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
PLoS ONE, 2023 Improper regulation of translation initiation, a vital checkpoint of protein synthesis in the cell, has been linked to a number of cancers. Overexpression of protein subunits of eukaryotic translation initiation factor 3 (eIF3) is associated with ...
Marina P Volegova +2 more
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Non-AUG translation initiation in mammals
Genome Biology, 2022 Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA.
Dmitry E. Andreev +5 more
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A translation initiation element specific to mRNAs with very short 5'UTR that also regulates transcription. [PDF]
PLoS ONE, 2008 Transcription is controlled by cis regulatory elements, which if localized downstream to the transcriptional start site (TSS), in the 5'UTR, could influence translation as well.
Rofa Elfakess, Rivka Dikstein
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Translation Initiation Factors eIF3 and HCR1 Control Translation Termination and Stop Codon Read-Through in Yeast Cells [PDF]
, 2013 Translation is divided into initiation, elongation, termination and ribosome recycling. Earlier work implicated several eukaryotic initiation factors (eIFs) in ribosomal recycling in vitro.
Lucie Cuchalová +20 more
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eLife, 2016 Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown.
Ryuta Ishimura +4 more
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Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]
, 2013 Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias.
Kazana, Eleanna +5 more
core +1 more source