Results 1 to 10 of about 315,675 (113)
Unbiased screen of human transcriptome reveals an unexpected role of 3’UTRs in translation initiation [PDF]
Nature CommunicationsAlthough most eukaryotic mRNAs require a 5ʹ-cap for translation initiation, some can also be translated through a poorly studied cap-independent pathway.
Yun Yang +12 more
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Mechanisms of human mitochondrial leaderless mRNA translation initiation [PDF]
Nature CommunicationsMitochondrial translation is essential for cellular function, and its dysregulation is associated with mitochondrial disorders and cancer. However, the mechanisms by which human mitochondrial ribosomes initiate translation remain poorly understood ...
Shuangjie Shen +3 more
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NetStart 2.0: prediction of eukaryotic translation initiation sites using a protein language model [PDF]
BMC BioinformaticsBackground Accurate identification of translation initiation sites is essential for the proper translation of mRNA into functional proteins. In eukaryotes, the choice of the translation initiation site is influenced by multiple factors, including its ...
Line Sandvad Nielsen +3 more
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Scientific Reports, 2021 Cap-independent translation initiation plays crucial roles in fine-tuning gene expression under global translation shutdown conditions. Translation of uncapped or de-capped transcripts can be stimulated by Cap-independent translation enhancer (CITE ...
Brandon M. Trainor +4 more
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Proteostasis is differentially modulated by inhibition of translation initiation or elongation
eLife, 2023 Recent work has revealed an increasingly important role for mRNA translation in maintaining proteostasis. Here, we use chemical inhibitors targeting discrete steps of translation to compare how lowering the concentration of all or only translation ...
Khalyd J Clay +3 more
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Leveraging genome-wide datasets to quantify the functional role of the anti-Shine–Dalgarno sequence in regulating translation efficiency [PDF]
Open Biology, 2017 Studies dating back to the 1970s established that sequence complementarity between the anti-Shine–Dalgarno (aSD) sequence on prokaryotic ribosomes and the 5′ untranslated region of mRNAs helps to facilitate translation initiation. The optimal location of
Adam J. Hockenberry +3 more
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Zdorovʹe Rebenka, 2022 The scientific review considers the mechanisms of action of cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during the initiation and post-initiation period of translation.
A.E. Abaturov, V.L. Babуch
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PLoS ONE, 2022 A number of neurologic diseases associated with expanded nucleotide repeats, including an inherited form of amyotrophic lateral sclerosis, have an unconventional form of translation called repeat-associated non-AUG (RAN) translation.
Alec C Gleason +4 more
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The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
PLoS ONE, 2023 Improper regulation of translation initiation, a vital checkpoint of protein synthesis in the cell, has been linked to a number of cancers. Overexpression of protein subunits of eukaryotic translation initiation factor 3 (eIF3) is associated with ...
Marina P Volegova +2 more
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Non-AUG translation initiation in mammals
Genome Biology, 2022 Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA.
Dmitry E. Andreev +5 more
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