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Mechanisms of human mitochondrial leaderless mRNA translation initiation [PDF]
Nature CommunicationsMitochondrial translation is essential for cellular function, and its dysregulation is associated with mitochondrial disorders and cancer. However, the mechanisms by which human mitochondrial ribosomes initiate translation remain poorly understood ...
Shuangjie Shen +3 more
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Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells [PDF]
eLifeTranslation initiation in eukaryotes requires a 40 S ribosome loaded with initiator tRNA which scans for an initiation codon. The initiator tRNA is usually recruited to the ribosome as part of a ternary complex composed of initiator tRNA, eIF2, and GTP ...
Mykola Roiuk +2 more
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NetStart 2.0: prediction of eukaryotic translation initiation sites using a protein language model [PDF]
BMC BioinformaticsBackground Accurate identification of translation initiation sites is essential for the proper translation of mRNA into functional proteins. In eukaryotes, the choice of the translation initiation site is influenced by multiple factors, including its ...
Line Sandvad Nielsen +3 more
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Transcriptome-wide mapping of small ribosomal subunits elucidates scanning mechanisms of translation initiation in the mammalian brain [PDF]
Communications BiologyNeuronal protein synthesis is highly compartmentalised and regulated, with key roles for translation initiation and elongation factors. Ribosome profiling, the most widely used transcriptome-wide method for measuring translation, captures translation ...
Preeti Madhav Kute +4 more
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Scientific Reports, 2021 Cap-independent translation initiation plays crucial roles in fine-tuning gene expression under global translation shutdown conditions. Translation of uncapped or de-capped transcripts can be stimulated by Cap-independent translation enhancer (CITE ...
Brandon M. Trainor +4 more
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Proteostasis is differentially modulated by inhibition of translation initiation or elongation
eLife, 2023 Recent work has revealed an increasingly important role for mRNA translation in maintaining proteostasis. Here, we use chemical inhibitors targeting discrete steps of translation to compare how lowering the concentration of all or only translation ...
Khalyd J Clay +3 more
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Unnatural Translation Initiation [PDF]
ACS Chemical Biology, 2008 Protein translation in nature always begins with an initiator transfer RNA (tRNA) carrying the amino acid methionine. This was circumvented in vitro with a reconstituted translation system utilizing initiator tRNA synthetically mischarged with the other natural amino acids.
John W, Tomsho, Stephen J, Benkovic
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Zdorovʹe Rebenka, 2022 The scientific review considers the mechanisms of action of cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during the initiation and post-initiation period of translation.
A.E. Abaturov, V.L. Babуch
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Modifications on Translation Initiation [PDF]
Cell, 2015 Two studies by Meyer et al. and Wang et al. demonstrate a role for m(6)A modification of mRNA in stimulating translation initiation. These findings add to the growing number of diverse mechanisms for translation initiation in eukaryotes.
Mitchell, Sarah F., Parker, Roy
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Translation initiation of viral mRNAs [PDF]
Reviews in Medical Virology, 2010 AbstractViruses depend on cells for their replication but have evolved mechanisms to achieve this in an efficient and, in some instances, a cell‐type‐specific manner. The expression of viral proteins is frequently subject to translational control. The dominant target of such control is the initiation step of protein synthesis.
Lopez-Lastra, Marcelo +5 more
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