Results 11 to 20 of about 314,589 (303)
Modifications on Translation Initiation [PDF]
Cell, 2015 Two studies by Meyer et al. and Wang et al. demonstrate a role for m6A modification of mRNA in stimulating translation initiation.
Mitchell, Sarah F., Parker, Roy
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Translation | Translation Initiation in Bacteria: Factors and Mechanisms
, 2021 Bacterial translation initiation pathway entails several steps kinetically controlled by initiation factors IF1, IF2 and IF3. The pathway begins with formation of the 30S pre-initiation complex containing all 30S ligands followed by a locking step ...
Claudio O. Gualerzi +3 more
core +2 more sources
EcoSal Plus, 2011 International audienceSelection of correct start codons on mRNAs is a key step required for faithful translation of the genetic message. Such a selection occurs in a complex process, during which a translation-competent ribosome assembles, eventually ...
Mechulam, Yves +2 more
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Unnatural Translation Initiation [PDF]
ACS Chemical Biology, 2008 Protein translation in nature always begins with an initiator transfer RNA (tRNA) carrying the amino acid methionine. This was circumvented in vitro with a reconstituted translation system utilizing initiator tRNA synthetically mischarged with the other natural amino acids.
John W, Tomsho, Stephen J, Benkovic
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Translation initiation of viral mRNAs [PDF]
Reviews in Medical Virology, 2010 AbstractViruses depend on cells for their replication but have evolved mechanisms to achieve this in an efficient and, in some instances, a cell‐type‐specific manner. The expression of viral proteins is frequently subject to translational control. The dominant target of such control is the initiation step of protein synthesis.
Lopez-Lastra, Marcelo +5 more
openaire +6 more sources
Non-AUG translation initiation in mammals
Genome Biology, 2022 Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA.
Dmitry E. Andreev +5 more
doaj +1 more source
Translation initiation in cancer at a glance [PDF]
Journal of Cell Science, 2021 ABSTRACT Cell division, differentiation and function are largely dependent on accurate proteome composition and regulated gene expression. To control this, protein synthesis is an intricate process governed by upstream signalling pathways.
Rachael C. L. Smith +6 more
openaire +3 more sources
A translation initiation element specific to mRNAs with very short 5'UTR that also regulates transcription. [PDF]
PLoS ONE, 2008 Transcription is controlled by cis regulatory elements, which if localized downstream to the transcriptional start site (TSS), in the 5'UTR, could influence translation as well.
Rofa Elfakess, Rivka Dikstein
doaj +1 more source
Translation Initiation Factors eIF3 and HCR1 Control Translation Termination and Stop Codon Read-Through in Yeast Cells [PDF]
, 2013 Translation is divided into initiation, elongation, termination and ribosome recycling. Earlier work implicated several eukaryotic initiation factors (eIFs) in ribosomal recycling in vitro.
Lucie Cuchalová +20 more
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eLife, 2016 Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown.
Ryuta Ishimura +4 more
doaj +1 more source