Results 11 to 20 of about 1,545,528 (302)

Modifications on Translation Initiation [PDF]

Cell, 2015
Two studies by Meyer et al. and Wang et al. demonstrate a role for m(6)A modification of mRNA in stimulating translation initiation. These findings add to the growing number of diverse mechanisms for translation initiation in eukaryotes.
Mitchell, Sarah F., Parker, Roy
core   +6 more sources

Unnatural Translation Initiation [PDF]

ACS Chemical Biology, 2008
Protein translation in nature always begins with an initiator transfer RNA (tRNA) carrying the amino acid methionine. This was circumvented in vitro with a reconstituted translation system utilizing initiator tRNA synthetically mischarged with the other natural amino acids.
John W, Tomsho, Stephen J, Benkovic
openaire   +2 more sources

Translation initiation of viral mRNAs [PDF]

Reviews in Medical Virology, 2010
AbstractViruses depend on cells for their replication but have evolved mechanisms to achieve this in an efficient and, in some instances, a cell‐type‐specific manner. The expression of viral proteins is frequently subject to translational control. The dominant target of such control is the initiation step of protein synthesis.
Lopez-Lastra, Marcelo, Ramdohr, Pablo, Letelier, Alejandro, Vallejos, Maricarmen, Vera-Otarola, Jorge, Valiente-Echeverria, Fernando   +5 more
openaire   +6 more sources

Translation initiation in cancer at a glance [PDF]

Journal of Cell Science, 2021
ABSTRACT Cell division, differentiation and function are largely dependent on accurate proteome composition and regulated gene expression. To control this, protein synthesis is an intricate process governed by upstream signalling pathways.
Rachael C. L. Smith, Georgios Kanellos, Nikola Vlahov, Constantinos Alexandrou, Anne E. Willis, John R. P. Knight, Owen J. Sansom   +6 more
openaire   +3 more sources

A translation initiation element specific to mRNAs with very short 5'UTR that also regulates transcription. [PDF]

PLoS ONE, 2008
Transcription is controlled by cis regulatory elements, which if localized downstream to the transcriptional start site (TSS), in the 5'UTR, could influence translation as well.
Rofa Elfakess, Rivka Dikstein
doaj   +1 more source

Translation Initiation Factors eIF3 and HCR1 Control Translation Termination and Stop Codon Read-Through in Yeast Cells [PDF]

, 2013
Translation is divided into initiation, elongation, termination and ribosome recycling. Earlier work implicated several eukaryotic initiation factors (eIFs) in ribosomal recycling in vitro.
Lucie Cuchalová, Lucie Cuchalová (153753), Wagner, Susan, Valasek, Leos S, Cuchalova, Lucie, Petra Beznosková (488568), Susan Wagner, Shoemaker, Christopher J, von der Haar, Tobias, Christopher J Shoemaker, Stanislava Gunišová (153731), Susan Wagner (488569), Beznoskova, Petra, Christopher J. Shoemaker (259606), Leoš Shivaya Valášek (153772), Gunisova, Stanislava, Stanislava Gunišová, Tobias von der Haar, Tobias von der Haar (80575), Petra Beznosková, Leoš Shivaya Valášek   +20 more
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Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

eLife, 2016
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown.
Ryuta Ishimura, Gabor Nagy, Ivan Dotu, Jeffrey H Chuang, Susan L Ackerman   +4 more
doaj   +1 more source

A comprehensive analysis of the importance of translation initiation factors for Haloferax volcanii applying deletion and conditional depletion mutants [PDF]

, 2013
Translation is an important step in gene expression. The initiation of translation is phylogenetically diverse, since currently five different initiation mechanisms are known.
Jörg Soppa, Schmitt, Jessica, Schulz, Sebastian, Näther, Daniela, Katrin Gäbel (484917), Jessica Schmitt (147351), Katrin Gäbel, Gäbel, Katrin, Daniela J Näther, Sebastian Schulz, Soppa, Jörg, Sebastian Schulz (484918), Jörg Soppa (23130), Daniela J. Näther (484919), Jessica Schmitt   +14 more
core   +1 more source

The MATH-BTB Protein TaMAB2 Accumulates in Ubiquitin-Containing Foci and Interacts With the Translation Initiation Machinery in Arabidopsis

Frontiers in Plant Science, 2019
MATH-BTB proteins are known to act as substrate-specific adaptors of CUL3-based E3 ligases in the ubiquitin proteasome pathway. Their BTB domain binds to CUL3 scaffold proteins and the less conserved MATH domain targets a highly diverse collection of ...
Nataša Bauer, Andreja Škiljaica, Nenad Malenica, Genadij Razdorov, Marija Klasić, Martina Juranić, Marko Močibob, Stefanie Sprunck, Thomas Dresselhaus, Dunja Leljak Levanić   +9 more
doaj   +1 more source

Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]

, 2013
Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias.
Kazana, Eleanna, von der Haar, Tobias, Bellanger, Noémie, Singh, Tarun, Chu, Dominique, Tuite, Mick F.   +5 more
core   +1 more source