Results 11 to 20 of about 1,605,540 (300)

Modifications on Translation Initiation [PDF]

Cell, 2015
Two studies by Meyer et al. and Wang et al. demonstrate a role for m(6)A modification of mRNA in stimulating translation initiation. These findings add to the growing number of diverse mechanisms for translation initiation in eukaryotes.
Mitchell, Sarah F., Parker, Roy
openaire   +4 more sources

Translation initiation in cancer at a glance [PDF]

Journal of Cell Science, 2021
ABSTRACT Cell division, differentiation and function are largely dependent on accurate proteome composition and regulated gene expression. To control this, protein synthesis is an intricate process governed by upstream signalling pathways.
Rachael C. L. Smith, Georgios Kanellos, Nikola Vlahov, Constantinos Alexandrou, Anne E. Willis, John R. P. Knight, Owen J. Sansom   +6 more
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Unbiased screen of human transcriptome reveals an unexpected role of 3’UTRs in translation initiation [PDF]

Nature Communications
Although most eukaryotic mRNAs require a 5ʹ-cap for translation initiation, some can also be translated through a poorly studied cap-independent pathway.
Yun Yang, Xiaojuan Fan, Yanwen Ye, Zhenzhen Zhang, Chuyun Chen, Sebastian E. J. Ludwig, Sirui Zhang, Qianyun Lu, Cindy L. Will, Henning Urlaub, Jing Sun, Reinhard Lührmann, Zefeng Wang   +12 more
doaj   +2 more sources

Translation | Translation Initiation in Bacteria: Factors and Mechanisms

, 2021
Bacterial translation initiation pathway entails several steps kinetically controlled by initiation factors IF1, IF2 and IF3. The pathway begins with formation of the 30S pre-initiation complex containing all 30S ligands followed by a locking step stabilizing the P-site decoding of the mRNA initiation triplet (AUG in most cases) by fMet-tRNAfmet ...
Gualerzi C. O., Giuliodori A. M.
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Translation Initiation

EcoSal Plus, 2011
Selection of correct start codons on messenger RNAs is a key step required for faithful translation of the genetic message. Such a selection occurs in a complex process, during which a translation-competent ribosome assembles, eventually having in its P site a specialized methionyl-tRNA Met base-paired with the ...
Mechulam, Yves, Blanquet, Sylvain, Schmitt, Emmanuelle   +2 more
core   +5 more sources

Mechanisms of human mitochondrial leaderless mRNA translation initiation [PDF]

Nature Communications
Mitochondrial translation is essential for cellular function, and its dysregulation is associated with mitochondrial disorders and cancer. However, the mechanisms by which human mitochondrial ribosomes initiate translation remain poorly understood ...
Shuangjie Shen, Yinghua Xu, Daniel L. Kober, Jinfan Wang   +3 more
doaj   +2 more sources

NetStart 2.0: prediction of eukaryotic translation initiation sites using a protein language model [PDF]

BMC Bioinformatics
Background Accurate identification of translation initiation sites is essential for the proper translation of mRNA into functional proteins. In eukaryotes, the choice of the translation initiation site is influenced by multiple factors, including its ...
Line Sandvad Nielsen, Anders Gorm Pedersen, Ole Winther, Henrik Nielsen   +3 more
doaj   +2 more sources

A translation enhancer element from black beetle virus engages yeast eIF4G1 to drive cap-independent translation initiation

Scientific Reports, 2021
Cap-independent translation initiation plays crucial roles in fine-tuning gene expression under global translation shutdown conditions. Translation of uncapped or de-capped transcripts can be stimulated by Cap-independent translation enhancer (CITE ...
Brandon M. Trainor, Arnab Ghosh, Dimitri G. Pestov, Christopher U. T. Hellen, Natalia Shcherbik   +4 more
doaj   +1 more source

Proteostasis is differentially modulated by inhibition of translation initiation or elongation

eLife, 2023
Recent work has revealed an increasingly important role for mRNA translation in maintaining proteostasis. Here, we use chemical inhibitors targeting discrete steps of translation to compare how lowering the concentration of all or only translation ...
Khalyd J Clay, Yongzhi Yang, Christina Clark, Michael Petrascheck   +3 more
doaj   +1 more source

Unnatural Translation Initiation [PDF]

ACS Chemical Biology, 2008
Protein translation in nature always begins with an initiator transfer RNA (tRNA) carrying the amino acid methionine. This was circumvented in vitro with a reconstituted translation system utilizing initiator tRNA synthetically mischarged with the other natural amino acids.
John W, Tomsho, Stephen J, Benkovic
openaire   +2 more sources