Results 101 to 110 of about 90,174 (301)

Derivable affine planes and translation planes

open access: yesBulletin of the Belgian Mathematical Society - Simon Stevin, 2000
Let \(\mathcal A\) be an affine plane, \(\overline {\mathcal A}\) its projective extension, and \(W\) the line at infinity. Choose a non-trivial subset \(D \subset W\), and denote by \({\mathcal G}_D\) the set of all lines intersecting \(W\) in a point of~\(D\), by \({\mathcal B}_D\) the set of all Baer subplanes whose line at infinity consists exactly
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Translation & metaphor

open access: yes, 2005
Wong Suzanne Shu-Shan.Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.Includes bibliographical references (leaves 133-136).Abstracts in English and Chinese.Introduction --- p.1Chapter PART ONE --- Translation Process: A Metaphorical Mapping ...

core  

TelekineticDealer: Contactless Card Manipulation Using Airborne Ultrasound—Evaluation of Card Actuation Performance

open access: yesIEEE Access
We present TelekineticDealer, a method for acoustically manipulating cards placed on a flat platform. Strong airborne ultrasoud can apply a steady force on objects through the air.
Gakuto Arakawa   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

A characterization of translation hyperovals

open access: yes, 1997
A characterization of translation hyperovals in any translation plane of even order and one of regular hyperovals in Desarguesian planes of even order are given.
MASCHIETTI, Antonio
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Counting social interactions for discrete subsets of the plane

open access: yes, 2021
Thesis (Ph.D.)--University of Washington, 2021We will use dynamical, geometric, and analytic techniques to study translation surfaces. A translation surface is, informally, a collection of polygons in the plane with parallel sides identified by ...
Fairchild, Samantha Kay
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

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