Results 81 to 90 of about 513,946 (293)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
SYMMETRY OF TWO DIMENSIONAL PATTERNS
Journal of Industrial Design and Engineering Graphics, 2014 This paper identifies geometric concepts and constructions of symmetrical patterns which are of great value to design practitioners. Particular attention is focused on geometric symmetry as the basis of an analytical tool to examine designs in different ...
DOBRE Daniel
doaj
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Transposed translation planes [PDF]
Proceedings of the American Mathematical Society, 1975 A detailed study of the transposed translation planes which are also given by dual spreads is made using the matrix representation of translation planes.
openaire +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Separation-Sensitive Collision Detection for Convex Objects [PDF]
, 1998 We develop a class of new kinetic data structures for collision detection between moving convex polytopes; the performance of these structures is sensitive to the separation of the polytopes during their motion. For two convex polygons in the plane, let $
Erickson, Jeff +3 more
core +3 more sources
Quasifields of symplectic translation planes
Journal of Combinatorial Theory, Series A, 2009 Let \(V\) be a vector space over the field \(F\) and let \(\Sigma\) be a spread on \(V\), i.e.\ a covering of \(V\) by a collection of mutually complementary subspaces. If every element of \(\Sigma\) is totally isotropic w.r.t a non-degenerate symplectic bilinear form \(S : V\times V \rightarrow F\), then \(\Sigma\) is called a symplectic spread ...
openaire +2 more sources
On Transposed Translation Planes
Open Journal of Discrete Mathematics, 2012 This paper is devoted to the study of a translation plane π(C) associated with a t-spread set C and its transposed t-spread set C t. In this paper, an explicit matrix form of the inverse of an isomorphism from a translation plane into another translation plane associated with t-spread sets is derived and proved that two translation planes associated ...
K. Satyanarayana +1 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source