Results 111 to 120 of about 30,282 (293)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Translation Planes of Order 49 and their Automorphism Groups
, 1998 Using isomorphism invariants, we enumerate the translation planes of order 49 and determine their automorphism ...
U Dempwolff (13287315) +1 more
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
TRANSLATION PLANES OF ODD ORDER VIA DEMBOWSKI–OSTROM POLYNOMIALS [PDF]
We describe a class of translation planes whose orders are of the form q^n, where n is odd and q is an odd prime power > 3. These planes have the property that a translation complement fixes a triangle and acts transitively on the set of non-vertices of ...
Müller, Peter, Dempwolff, Ulrich
core +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Journal of Rehabilitation Sciences and Research, 2015 Background: The purpose of the present study was to examine the reliability of scapular kinematic measurements using motion analysis system in subjects with and without General Hypermobility Syndrome.
Salman Nazary-Moghadam1 +4 more
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Translation planes admitting a linear Abelian group of order $(q+1)^2$.
, 2009 Translation planes of order $q^2$ and spread in $PG(3,q)$, where $q$ is an odd prime power and $q^2-1$ has a $p$-primitive divisor, that admit a linear Abelian group of order $(q+1)^2$ containing at most three kernel homologies are shown to be associated
Esteban Diaz +3 more
core +2 more sources