Results 101 to 110 of about 1,183,588 (257)
Orthogonal Spreads and Translation Planes
, 1996 There have been a number of striking new results concerning translation planes of characteristic 2, obtained using orthogonal and symplectic spreads. The impetus for this came from coding theory. This paper surveys the geometric advances, while providing
William M. Kantor
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Flokki planes and cubic polynomials [PDF]
, 2010 Non-Desarguesian translation planes of order $q^2$ are constructed whenever $q=2^e\ge 16$ and $e$ isnot divisible by $3$. Each plane has kernel $\textnormal{GF}(q)$ andtranslation complement of order $q(q-1)^2 e$, with orbits of lengths$1,$ $q$ and $q^2-
Kantor, William M., Penttila, Tim
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Spreads and unitals in topological translation planes
, 2005 Bu çalışmada, topolojik öteleme düzlemlerinde yayılımlar ve birimlikler incelenmiştir. Birinci bölümde giriş, ikinci bölümde gerekli olan temel kavramlar verilmiştir.
Demirel, Oğuzhan
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Symplectic translation planes of even order
, 2006 Symplectic translation planes of even order are investigated. Such planes are characterised by the existence of completely regular line--ovals, and these line--ovals give rise to symmetric designs isomorphic to certain designs investigated by Kantor. The
MASCHIETTI, Antonio
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source