Results 71 to 80 of about 236,507 (264)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Translation Shifts in Gibran’s The Prophet
مجلة العلوم التربوية و الدراسات الإنسانيةThis research paper aimed at investigating translation shifts in two Arabic translations of Gibran’s The Prophet, using Leuven-Zwart’s comparative and descriptive model. The main objective of this paper was to identify the micro structural shifts that induced shifts on the macro structural level and to analyze their consequences on the general meaning ...
Abdul-Kawi Hizam M. al-Shamiri +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Arthroscopic Load-Shift Technique for Intraoperative Assessment of Shoulder Translation
Arthroscopy Techniques, 2018 Shoulder instability represents a spectrum of disease, ranging from subluxation to dislocation. It may present acutely after trauma or chronically as a result of multiple events.
Steven F. DeFroda, M.D., M.E. +1 more
doaj +1 more source
Shifts in Indonesian-French Poem Translation
Lingual: Journal of Language and Culture, 2016 This paper aims at analyzing the translation shifts of a poem containing figurative expressions from Indonesian into French and describing the translation principles occur in the shifts. The data in this paper is an Indonesian poem with the title “Gestural Tubuh Perempuan” and its translation in French.
Putu Weddha Savitri +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Prasasti: Journal of Linguistics, 2017 Background: The research aims to (1) identify the types of lexical cohesion taxonomic markers found in the novel Diary of a Wimpy Kid: Cabin Fever and its translation Diary si Bocah Tengil: Demam Kabin, (2) explain the shift of lexical cohesion taxonomic
Norma Noviana +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Translating songs between endangered and modernized languages: The case of Ryukyuan in Okinawa, Japan [PDF]
Studia TranslatoricaExamining the severely endangered languages of the Ryukyuan Archipelago from a translation studies perspective reveals that song is the only domain where translation is occurring, and that this translation has hardly been researched.
Matthew Guay
doaj +1 more source