Results 111 to 120 of about 1,513,840 (316)

Outcome assessment in veterinary pain studies: a pain in animals workshop (PAW) perspective

Frontiers in Pain Research
Biennially, the Pain in Animals Workshop (PAW) forum brings together scientists and clinicians to focus, across veterinary species and humans, on our shared passion of improving health through our ability to recognize and monitor pain. This collaboration
D. C. Brown, J. Coetzee, M. Gill, C. Johnson, D. P. Mohapatra, M. L. Oshinsky, S. A. Robertson, E. R. Smith, B. D. X. Lascelles, B. D. X. Lascelles, B. D. X. Lascelles   +10 more
doaj   +1 more source

The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders

Frontiers in Pharmacology, 2013
There is ample evidence that genetic factors play an important role in anxiety disorders. In support, human genome-wide association studies have implicated several novel candidate genes.
Jocelien DA Olivier, Jocelien DA Olivier, Christiaan H Vinkers, Christiaan H Vinkers, Berend eOlivier, Berend eOlivier   +5 more
doaj   +1 more source

UMCCTS Newsletter, November 2024

This is the Novembr 2024 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through ...
UMass Center for Clinical and Translational Science
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

UMCCTS Newsletter, May 2025

This is the May 2025 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grants ...
UMass Center for Clinical and Translational Science
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Bioethical and critical consciousness in clinical translational neuroscience

Journal of Clinical and Translational Science
Clinical translational neuroscience (CTN) is positioned to generate novel discoveries for advancing treatments for mental health disorders, but it is held back today by the siloing of bioethical considerations from critical consciousness. In this article,
Angela Fang, Riana Elyse Anderson, Sierra Carter, Kristen Eckstrand, Kean J. Hsu, Shawn Jones, Maria Kryza-Lacombe, Andrew Peckham, Greg J. Siegle, Lucina Q. Uddin, Mariann Weierich, Mary L. Woody, Judy Illes   +12 more
doaj   +1 more source

Translation as a Process and Translation as a Product in Teaching Translation

Sintagma, 2003
L'ensenyament de la traducció s'ha utilitzat tradicionalment en algunes titulacions de filologia com a eina d'aprenentatge d'habilitats de la llengua. Aquesta circumstància, però, no ha d'estar renyida amb la producció d'una traducció acceptable. En aquest article es pretén analitzar si pot aconseguir-se aquest objectiu mitjançant la incorporació d ...
openaire   +3 more sources

UMCCTS Newsletter, August 2024

This is the August 2024 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through ...
UMass Center for Clinical and Translational Science
core   +1 more source