Results 91 to 100 of about 1,513,840 (316)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Editorial: Environmental Enrichment as a Treatment? Epigenetic Mechanisms, Challenges and Limitations

Frontiers in Pharmacology, 2021
Rosa Redolat, Patricia Mesa-Gresa, Patricia Sampedro-Piquero, Debora Cutuli   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

To Translate or not to Translate? [PDF]

Meta: Journal des traducteurs, 1985
A partir d'exemples sur les difficultes de la traduction tirees de la litterature et en particulier de la poesie («les correspondances» de Baudelaire), est recense l'ensemble des problemes, souvent incontournables que pose la langue a un traducteur charge de trouver d'une langue a une autre un concept ...
openaire   +2 more sources

A translational framework for public health research [PDF]

, 2009
<p><b>Background</b></p> <p>The paradigm of translational medicine that underpins frameworks such as the Cooksey report on the funding of health research does not adequately reflect the complex reality of the public health ...
Griffin, S., Wareham Nicholas J, Macintyre, S., Peter Craig, Simon Griffin, Nicholas J Wareham, Craig Peter, Wareham, N., Ogilvie, D., Griffin Simon, David Ogilvie, Craig, P., Sally Macintyre, Macintyre Sally, Ogilvie David   +14 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Corrigendum: Translational Research Studies Unraveling the Origins of Psoriatic Arthritis: Moving Beyond Skin and Joints

Frontiers in Medicine, 2021
Janne W. Bolt, Janne W. Bolt, Janne W. Bolt, Chaja M. J. van Ansenwoude, Chaja M. J. van Ansenwoude, Chaja M. J. van Ansenwoude, Ihsan Hammoura, Ihsan Hammoura, Ihsan Hammoura, Marleen G. van de Sande, Marleen G. van de Sande, Marleen G. van de Sande, Lisa G. M. van Baarsen, Lisa G. M. van Baarsen, Lisa G. M. van Baarsen   +14 more
doaj   +1 more source

UMCCTS Newsletter, February 2025

This is the February 2025 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through ...
UMass Center for Clinical and Translational Science
core   +1 more source

Academic-industry collaborations in translational stroke research

, 2022
S.343-353Academic-industry collaborations are an emerging format of translational stroke research. Next to classic contract research models, a multitude of collaboration models has been developed, some of which even allowing for multinational or ...
Gounis, Matthew J., Wagner, Daniel-Christoph, Barthel, Henryk, Boltze, Johannes   +3 more
core   +1 more source