Results 91 to 100 of about 2,149,735 (308)

Self-diffusion in two-dimensional hard ellipsoid suspensions [PDF]

open access: yes, 2010
We studied the self-diffusion of colloidal ellipsoids in a monolayer near a flat wall by video microscopy. The image processing algorithm can track the positions and orientations of ellipsoids with sub-pixel resolution.
Berne B. J.   +3 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Editorial: Bench to bedside: translating pre-clinical research into clinical trials for childhood brain tumors

open access: yesFrontiers in Oncology, 2023
Raelene Endersby   +5 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons

open access: yesFrontiers in Pharmacology, 2018
Midbrain dopamine (DA) neurons are considered a critical substrate for the reinforcing and sensitizing effects of nicotine and tobacco dependence. While the role of the α4 and β2 subunit containing nicotinic acetylcholine receptors (α4β2∗nAChRs) in ...
Ginetta Collo   +7 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Corrigendum: Gene therapy approaches for equine osteoarthritis

open access: yesFrontiers in Veterinary Science, 2023
Parvathy Thampi   +5 more
doaj   +1 more source

A ball trunnion capture latch [PDF]

open access: yes, 1982
The Ball Trunnion Capture Latch described was developed and designed to restrain a spacecraft deployable appendage in three translational directions. The latch is capable of supporting an appendage during STS ascent and landing events and is capable of ...
Adams, D. V., Alchorn, B.
core   +1 more source

Aperiodic Tilings: Breaking Translational Symmetry

open access: yes, 2005
Classical results on aperiodic tilings are rather complicated and not widely understood. Below, an alternative approach is discussed in hope to provide additional intuition not apparent in classical works.Comment: 4 pages, 2 figures, minor ...
Levin, Leonid A.
core   +1 more source

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