Results 111 to 120 of about 54,971,060 (296)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Taking Flight to Disseminate Translational Research: A Partnership between the UMass Center for Clinical and Translational Science and the Library’s Institutional Repository [PDF]
, 2017 eScholarship@UMMS is the University of Massachusetts Medical School’s open access digital archive of research and scholarship, managed by the Lamar Soutter Library.
Gore, Sally A., Palmer, Lisa A.
core
The "Salmon Spirit" of translational medical research. [PDF]
Ann Transl Med, 2020 Lu L.
europepmc +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
, 2015 This report presents the proceedings of the Irish Health Research Forum on May 12th, 2015 on developing a process to prioritise health research questions for policy, practice and ...
Medical Research Charities Group
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
, 2015 Following the first meeting of the Irish Health Research Forum IHRF (4th November 2014), the attendees voted to discuss at the next gathering “A process to prioritise research questions for policy, practice and services”.
Medical Research Charities Group
core
Como usar a abordagem da Política Informada por Evidência na saúde pública?
Saúde em DebateRESUMO A Política Informada por Evidência (PIE) surgiu para identificar as melhores estratégias disponíveis, nos aproximando do processo de tomada de decisão em políticas públicas.
Maíra Catharina Ramos +1 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source