Results 81 to 90 of about 3,424,855 (336)

Do medicine and cell biology talk to each other? A study of vocabulary similarities between fields

Brazilian Journal of Medical and Biological Research, 2021
A close interaction between basic science and applied medicine is to be expected. Therefore, it is important to measure how far apart the field of cell biology and medicine are.
S. Azevedo, M.R. Seixas, A.D. Jurberg, C. Mermelstein, M.L. Costa   +4 more
doaj   +1 more source

Lost in Translation: Obstacles to Translational Medicine [PDF]

Journal of Translational Medicine, 2004
When we launched the Journal of Translational Medicine a few months ago, we were interested primarily in exploring scientific consideration of this discipline. However, as editors of JTM, we have been contacted almost daily to discuss the problems faced by scientists and clinicians around the world who are challenging the traditional boundaries of ...
Mankoff, Stacey P., Brander, Christian, Ferrone, Soldano, Marincola, Francesco M.   +3 more
openaire   +4 more sources

Academia Europaea Position Paper on Translational Medicine: The Cycle Model for Translating Scientific Results into Community Benefits

Journal of Clinical Medicine, 2020
Introduction: Translational science has gained prominence in medicine, but there is still much work to be done before scientific results are used optimally and incorporated into everyday health practice.
P. Hegyi, O. Petersen, S. Holgate, B. Erőss, A. Garami, Z. Szakács, D. Dobszai, M. Balaskó, L. Kemény, Shuang Peng, Joao Monteiro, A. Varró, T. Lamont, J. Laurence, Zoe Gray, A. Pickles, G. FitzGerald, C. Griffiths, J. Jassem, D. Rusakov, A. Verkhratsky, A. Szentesi   +21 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Allogeneic Stem Cells Alter Gene Expression and Improve Healing of Distal Limb Wounds in Horses. [PDF]

, 2017
Distal extremity wounds are a significant clinical problem in horses and humans and may benefit from mesenchymal stem cell (MSC) therapy. This study evaluated the effects of direct wound treatment with allogeneic stem cells, in terms of gross, histologic,
Aristizobal, Fabio A, Bledsoe, Andrea, Bohannon-Worsley, Laurie K, Borjesson, Dori L, Clark, Kaitlin C, Davidyan, Arik, Gray, Sarah N, Kol, Amir, LeJeune, Sarah S, Textor, Jamie A, Walker, Naomi J, Woolard, Kevin D   +11 more
core   +1 more source

Verification, Analytical Validation, and Clinical Validation (V3): The Foundation of Determining Fit-for-Purpose for Biometric Monitoring Technologies (BioMeTs) [PDF]

, 2020
Digital medicine is an interdisciplinary field, drawing together stakeholders with expertize in engineering, manufacturing, clinical science, data science, biostatistics, regulatory science, ethics, patient advocacy, and healthcare policy, to name a few.
Bakker, Jessie, Bent, Brinnae, Coravos, Andrea, Dowling, Ariel, Fitzer-Attas, Cheryl, Godfrey, Alan, Godino, Job, Goldsack, Jennifer, Gujar, Ninad, Ismailova, Elena, Manta, Christine, Peterson, Barry, Vandendriessche, Benjamin, Wang, Ke, Wood, William   +14 more
core   +2 more sources

A global resource to translational medicine: the International Park of Translational Medicine and BioMedicine (IPTBM)

Journal of Translational Medicine, 2013
Translational science consists of research and development that integrates multiple resources to expedite the successful treatment of disease. The International Park of Translational BioMedicine (IPTBM) is currently being developed within the interface ...
Wu Xiaodan, Marincola Francesco M, Liebman Michael N, Wang Xiangdong   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Tricks to translating TB transcriptomics. [PDF]

, 2015
Transcriptomics and other high-throughput methods are increasingly applied to questions relating to tuberculosis (TB) pathogenesis. Whole blood transcriptomics has repeatedly been applied to define correlates of TB risk and has produced new insight into ...
Coussens, AK, Deffur, A, Wilkinson, RJ
core   +1 more source