Results 91 to 100 of about 617,976 (302)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

mRNA-specific translational regulation in yeast

, 2019
The expression of a gene is governed at various levels, from transcriptional to translational level. The translational control is widely used to regulate gene expression, especially when a rapid, local, and selective control over protein synthesis is ...
Bengü ERGÜDEN
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mechanisms of microRNA mediated gene silencing in C. elegans [PDF]

, 2009
Mechanisms of microRNA mediated gene silencing in C. elegans Xavier Ding Dissertation abstract microRNAs (miRNAs) are a large family of small non-coding RNAs, which post-transcriptionally repress numerous genes; a type of regulation which is ...
Ding, Xavier
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Translational Regulation of Cytoplasmic mRNAs

, 2014
Translation of the coding potential of a messenger RNA into a protein molecule is a fundamental process in all living cells and consumes a large fraction of metabolites and energy resources in growing cells.
von Arnim, Albrecht G., Roy, Bijoyita
core   +1 more source

Translational regulation shapes the molecular landscape of complex disease phenotypes [PDF]

, 2015
The extent of translational control of gene expression in mammalian tissues remains largely unknown. Here we perform genome-wide RNA sequencing and ribosome profiling in heart and liver tissues to investigate strain-specific translational regulation in ...
Silhavy, J, Cuppen, E., van Heesch, S, Schafer, Sebastian, Vingron, M, Pravenec, Michal, Silhavy, Jan, Heinig, M., van Heesch, S., Heinig, M, Rajewsky, N., Pravenec, M., Rodrigues, KEC, Cook, SA, Simaite, D., Pravenec, M, Rodrigues, Katharina E Costa, Schafer, S, Cuppen, E, Heinig, Matthias, Kreuchwig, Franziska, Rodrigues, K., Rajewsky, Nikolaus, Cook, Stuart A, Schafer, S., Costa Rodrigues, K.E., Vingron, Martin, Cook, S.A., Adami, E, Rajewsky, N, Simaite, Deimante, Van Heesch, Sebastiaan, Hubner, Norbert, Hubner, N, Cook, S., Cook, Stuart A., Adami, Eleonora, Kreuchwig, F., Adami, E., Hubner, N., Cuppen, Edwin, Simaite, D, Vingron, M., Kreuchwig, F, Silhavy, J.   +44 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Translational and post-translational regulation of polyamine metabolic enzymes in plants.

, 2021
Polyamines are small organic and basic polycations that perform essential regulatory functions in all living organisms. Fluctuations in polyamine content have been observed to occur during growth, development and under stress conditions, implying that ...
Guerrero-González, M L, Jasso-Robles, F I, Chávez-Martínez, A I, Liu, Ji-Hong, Ortega-Amaro, M A, Gill, Sarvajeet Singh, Jiménez-Bremont, J F, Maruri Lopez, Israel, Rodríguez-Kessler, M   +8 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source