Results 101 to 110 of about 1,824,000 (291)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Distinguishing between translational science and translational research in CTSA pilot studies: A collaborative project across 12 CTSA hubs

Journal of Clinical and Translational Science
Introduction: The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health.
Margaret Schneider, Amanda Woodworth, Marissa Ericson, Lindsie Boerger, Scott Denne, Pam Dillon, Paul Duguid, Eman Ghanem, Joe Hunt, Jennifer S. Li, Renee McCoy, Nadia Prokofieva, Vonda Rodriguez, Crystal Sparks, Jeffrey Zaleski, Henry Xiang   +15 more
doaj   +1 more source

Translational Research from an Informatics Perspective [PDF]

, 2007
Clinical and translational research (CTR) is an essential part of a sustainable global health system. Informatics is now recognized as an important en-abler of CTR and informaticians are increasingly called upon to help CTR efforts.
Bernstam, Elmer, Johnson-Throop, Kathy A., Meric-Bernstam, Funda, Smith, Jack W., Turley, James P.   +4 more
core   +1 more source

TRANSLATIONAL CKD RESEARCH [PDF]

Nephrology Dialysis Transplantation, 2014
Freedman, B.S., Lam, A.Q., Sundsbak, J.L., Morizane, R., Iatrino, R., Su, X., Koon, S.J., Wu, M., Daheron, L., Valerius, T., Harris, P.C., Zhou, J., Bonventre, J.V., Hwang, S.J., Lin, M.Y., Lee, H.L., Lin, H.L., Li, W.M., Wu, W.J., Huang, C.H., Chen, L.T., Yazawa, M., Kido, R., Kimura, K., Ohira, S., Hasegawa, T., Hanafusa, N., Iseki, K., Tsubakihara, Y., Shibagaki, Y., Kotwal, S., Webster, A., Cass, A., Gallagher, M, Raimann, J.G., Usvyat, L.A., Vega-Vega, O., Penne, L., Kooman, J., van der Sande, F.M., Thijssen, S., Marcelli, D., Canaud, B., Levin, N.W., Wang, Y., Kotanko, P., Tripepi, G., Maas, R., Boger, R., Zoccali, C., Mallamaci, F.   +50 more
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

PoweREST: Statistical power estimation for spatial transcriptomics experiments to detect differentially expressed genes between two conditions.

PLoS Computational Biology
Recent advancements in spatial transcriptomics (ST) have significantly enhanced biological research in various domains. However, the high cost for current ST data generation techniques restricts the large-scale application of ST.
Lan Shui, Anirban Maitra, Ying Yuan, Ken Lau, Harsimran Kaur, Liang Li, Ziyi Li, Translational and Basic Science Research in Early Lesions Research Consortia   +7 more
doaj   +1 more source

181 Mapping Translational Research Collaborations: Insights from an IDeA Clinical and Translational Research Center

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Policy makers are interested in understanding scientific collaborations that translate knowledge into population health. The objective of this study is to compare the translational research collaboration of the Hispanic Alliance of ...
Carlamarie NoboaU, Mariela Lugo Picó, Luisa Morales, Vicmag Cabrera   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source