Results 101 to 110 of about 1,808,025 (321)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Taking the Translational Science Benefits Model from concept to operationalization: opportunities and challenges in defining impact using the Translational Science Benefits Model

Frontiers in Public Health
The Translational Science Benefits Model (TSBM) was developed to conceptualize and communicate the benefits and impact of translational research. While the TSBM was developed as a conceptual model rather than an operational process, it can be integrated ...
Jessica Sperling, Jessica Sperling, Eman Ghanem, Stella Quenstedt, Tarun Saxena   +4 more
doaj   +1 more source

Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major [PDF]

, 2019
Besides their medical relevance, Leishmania is an adequate model for studying post-transcriptional mechanisms of gene expression. In this microorganism, mRNA degradation/stabilization mechanisms together with translational control and post-translational ...
Aguado, Begoña, Corvo, Laura, Lombraña, Rodrigo, Rastrojo, Alberto, Requena, Jose M., Solana, Jose C.   +5 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

An annotation scheme and gold standard for Dutch-English word alignment [PDF]

, 2010
The importance of sentence-aligned parallel corpora has been widely acknowledged. Reference corpora in which sub-sentential translational correspondences are indicated manually are more labour-intensive to create, and hence less wide-spread.
Macken, Lieve
core  

OTHR-10. COLLABORATIVE EFFORTS FOR HOSPITAL-BASED BIOBANK DEVELOPMENT AND OPTIMIZATION TO ENSURE QUALITY PEDIATRIC SPECIMENS FOR TRANSLATIONAL RESEARCH [PDF]

, 2023
Brittany Lebert, Maxine N. Gonzalez-Vega, Samer K. Elbabaa, Julia Hegert, Avery Wright, Ana Aguilar-Bonilla, Amy Smith   +6 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Distinguishing between translational science and translational research in CTSA pilot studies: A collaborative project across 12 CTSA hubs

Journal of Clinical and Translational Science
Introduction: The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health.
Margaret Schneider, Amanda Woodworth, Marissa Ericson, Lindsie Boerger, Scott Denne, Pam Dillon, Paul Duguid, Eman Ghanem, Joe Hunt, Jennifer S. Li, Renee McCoy, Nadia Prokofieva, Vonda Rodriguez, Crystal Sparks, Jeffrey Zaleski, Henry Xiang   +15 more
doaj   +1 more source

Nanomedicine for the Treatment of Non-Hodgkin Lymphoma [PDF]

, 2019
Non-Hodgkin lymphoma, or NHL, is the predominant category of lymphoma. NHL is a type of lymphoid hematopoietic malignancy which approximately 70,000 Americans are diagnosed with annually, with the number of diagnoses growing annually.
Gandhi, B.Pharm, Tanvi
core   +1 more source

TRANSLATIONAL CKD RESEARCH [PDF]

Nephrology Dialysis Transplantation, 2014
Freedman, B.S., Lam, A.Q., Sundsbak, J.L., Morizane, R., Iatrino, R., Su, X., Koon, S.J., Wu, M., Daheron, L., Valerius, T., Harris, P.C., Zhou, J., Bonventre, J.V., Hwang, S.J., Lin, M.Y., Lee, H.L., Lin, H.L., Li, W.M., Wu, W.J., Huang, C.H., Chen, L.T., Yazawa, M., Kido, R., Kimura, K., Ohira, S., Hasegawa, T., Hanafusa, N., Iseki, K., Tsubakihara, Y., Shibagaki, Y., Kotwal, S., Webster, A., Cass, A., Gallagher, M, Raimann, J.G., Usvyat, L.A., Vega-Vega, O., Penne, L., Kooman, J., van der Sande, F.M., Thijssen, S., Marcelli, D., Canaud, B., Levin, N.W., Wang, Y., Kotanko, P., Tripepi, G., Maas, R., Boger, R., Zoccali, C., Mallamaci, F.   +50 more
openaire   +1 more source