Results 181 to 190 of about 1,807,370 (271)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Remarkable Responses to Chemoimmunotherapy in Ultra-Rare Urachal Cancer: A Case Series and Reverse Translational Research. [PDF]

MedComm (2020)
Kotani H, Sato S, Shigehara K, Saito D, Sakaguchi H, Nishiyama A, Matsumoto I, Mizokami A, Yano S, Taniguchi H.   +9 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Structural and functional comparative analysis of porcine and human salivary glands: a narrative review for translational research. [PDF]

J Mol Histol
Vanelli L, Florezi GP, Massoco C, Lourenço SV.   +3 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

The Translational Research Program in Cancer Differences across Populations. [PDF]

Cancer Epidemiol Biomarkers Prev
Figueiredo JC, Redwood D, Li L, Donato E, Fort D, Fox EE, Grady WM, Green H, Harrison TA, Haupt C, Hsu L, Hullar MAJ, Huyghe JR, Johnson W, Koehne AL, LaBrie SD, Lakey MA, Lin M, Loroña NC, Maresh GA, Matrana M, Mizrahi JD, Nash SH, Nguyen NT, Paruch JL, Phipps AI, Qu C, Randolph TW, Romo S, Thomas CE, Thomas S, Tiesinga J, Whitlow C, Yeung CCS, Yin H, Zibilich CM, Li CI, Thomas TK, Peters U.   +38 more
europepmc   +1 more source

Translational Research, Chemo-Bioinformatics [PDF]

, 2016
梅嵜 雅人, 池原 達郎
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Meta-evaluative practices of Clinical and Translational Research evaluators. [PDF]

J Clin Transl Sci
Giancola S, Stevenson JF, Philibert I.
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source