Results 51 to 60 of about 1,824,000 (291)
Focus on Translational Research
Molecular Plant-Microbe Interactions, 2014 Readers of this journal are well aware how far our field has progressed towards mechanistic understanding of pathogenesis and immunity. Almost concurrently, this new fundamental knowledge is being translated into new tools for reducing disease losses in ...
John M. McDowell +2 more
doaj +1 more source
Taurine as a biomarker for aging: A new avenue for translational research
Advances in Biomarker Sciences and Technology, 2023 The physiologic and irreversible process of ageing is accompanied by a wide range of structural and functional shifts at multiple different levels.
Animesh Acharjee
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Translational research in neuroanaesthesia
Journal of Neuroanaesthesiology and Critical Care, 2014 Translational research in anaesthesia provided great solutions to medicine, well beyond its scope, in the past. Exciting opportunities exist for neuroanaesthesiologists to conduct translational research not just in anaesthesia alone but in the wider ...
Ganne S. Umamaheswara Rao
doaj +1 more source
Concept Mapping to Develop a Framework for Characterizing Electronic Data Capture (EDC) Systems [PDF]
, 2008 CTSAs have brought about a push to find better EDC systems, which facilitate translational research. Based on the data management needs of a specific clinical/translational research lab, concept mapping was used to create a framework to evaluate EDCs ...
Anderson, Nicholas R +3 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Translational research as an integral part of work–based learning [PDF]
, 2019 Shelagh Keogh, Northumbria University, UK This paper explores the concept of translational research as an appropriate strategy for work based learning.
Fulton, John, Keogh, Shelagh
core
From metagenomics to the metagenome: Conceptual change and the rhetoric of translational genomic research [PDF]
, 2009 As the international genomic research community moves from the tool-making efforts of the Human Genome Project into biomedical applications of those tools, new metaphors are being suggested as useful to understanding how our genes work – and for ...
Huss, John Edward, Juengst, Eric Thomas
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Bioinformatics advances in saliva diagnostics [PDF]
, 2012 There is a need recognized by the National Institute of Dental & Craniofacial Research and the National Cancer Institute to advance basic, translational and clinical saliva research. The goal of the Salivaomics Knowledge Base (SKB) is to create
B Smith +17 more
core +2 more sources