Results 71 to 80 of about 1,824,000 (291)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A Survey Study of Roadblocks in Translational Science

Clinical and Translational Science
Clinical and translational science needs to address roadblocks to the translational processes. We conducted a survey at two institutions, a private medical school and a large public university, to understand the frequency and distribution of barriers and
Fasiha Kanwal, Christopher I. Amos, Katherine H. Sippel, Claudia Neuhauser, Ariel Harrison, Mary E. Dickinson, Charles Minard, Bettina M. Beech   +7 more
doaj   +1 more source

Translational research in psychiatry

Industrial Psychiatry Journal
Translational research in psychiatry bridges the gap between basic scientific discoveries and clinical applications, aiming to improve the diagnosis, treatment, and prevention of mental illnesses.
Vinay Singh Chauhan, Markanday Sharma
doaj   +1 more source

Excellence in Community-Engaged Research at Virginia Commonwealth University: A Compendium of Case Studies Developed Through a Faculty Learning Community [PDF]

, 2014
Since 2005, the Center for Teaching Excellence (CTE) at VCU has offered faculty learning communities (FLC) on a variety of teaching and learning issues.
Center for Clinical and Translational Research, Division of Community Engagement   +1 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

RegenBase: a knowledge base of spinal cord injury biology for translational research. [PDF]

, 2016
Spinal cord injury (SCI) research is a data-rich field that aims to identify the biological mechanisms resulting in loss of function and mobility after SCI, as well as develop therapies that promote recovery after injury.
Abeyruwan, Saminda W, Al-Ali, Hassan, Bixby, John L, Callahan, Alison, Ferguson, Adam R, Lemmon, Vance P, Popovich, Phillip G, Sakurai, Kunie, Shah, Nigam H, Visser, Ubbo   +9 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A One Health overview, facilitating advances in comparative medicine and translational research. [PDF]

, 2016
Table of contentsA1 One health advances and successes in comparative medicine and translational researchCheryl StroudA2 Dendritic cell-targeted gorilla adenoviral vector for cancer vaccination for canine melanomaIgor Dmitriev, Elena Kashentseva, Jeffrey ...
Baron, David A, Bergman, Philip J, Bryan, Jeffrey N, Calvet, James P, Coates, Joan R, Cook, James L, Curiel, David T, Dmitriev, Igor, Duan, Dongsheng, Engiles, Julie B, Gandolfi, Barbara, Gaurnier-Hausser, Anita, Gnanandarajah, Josephine S, Gray, Falon, Guloy, Amado S, Harman, Robert J, Hays, Harlen D, Henry, Carolyn J, Huebner, Margie, Jacobs, Marc, Johnson, Gary S, Johnson, Gayle C, Karanu, Francis N, Kashentseva, Elena, Katz, Martin L, Laughlin, Danielle, LeBlanc, Amy K, Likins, Lee, Lyons, Leslie A, Mason, Nicola J, O'Brien, Dennis P, O'Connor, Daniel, Paterson, Yvonne, Reinero, Carol, Rindt, Hans, Robb, Edward J, Sabbagh, Ubadah, Skaff, Andrew, Stannard, James P, Stroud, Cheryl, Treml, Laura S, Wallecha, Anu, Webster, Debra A, Weiss, Mark L, Wyckoff, Gerald J   +44 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A team-based translational journal club: Understanding the translational research highway

Journal of Clinical and Translational Science, 2019
The mission of the National Center for Advancing Translational Science (NCATS) is to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a ...
Carol Feghali-Bostwick, Jillian Harvey, Carissa Hasseler, Diana Lee-Chavarria, Perry Halushka   +4 more
doaj   +1 more source