Results 81 to 90 of about 619,448 (301)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
2234 Developing the future translational science workforce at the University of Iowa
Journal of Clinical and Translational Science, 2018 OBJECTIVES/SPECIFIC AIMS: To evaluate the extent to which the curriculum delivered via an innovative program, the Early Scholars Certificate in Clinical and Translational Science (CCTS) at the University of Iowa (UI), develops a translational science ...
James Torner +2 more
doaj +1 more source
The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data [PDF]
, 2018 Marsha Wilcox +12 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Quantitative Consensus in Systematic Reviews: Current and Future Challenges in Translational Science [PDF]
, 2018 Francesco Chiappelli +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Translating cultures of science [PDF]
, 2018 This essay focuses on conceptualisations of science as culture, drawing primarily on research from the field of science and technology studies. It first highlights differences between traditional, Western positivist views of science and more culturally oriented, constructivist perspectives. In doing so, it introduces a conceptualisation of culture that
openaire +2 more sources
Total quality management (tqm) and systems thinking in translational science [PDF]
, 2018 R. E. F. Smith
openalex +1 more source
Community-engaged research in translational science: Innovations to improve health in Appalachia [PDF]
, 2021 Scott D. Rhodes +9 more
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source