Results 41 to 50 of about 396,222 (280)

Global and local depletion of ternary complex limits translational elongation [PDF]

, 2010
Peer ...
Miekley, Oskar, Moura, Alessandro, Moura, A., Zhang, Gong, Miekley, O., Fedyunin, Ivan, Valleriani, Angelo, Ignatova, Z., Fedyunin, I., Ignatova, Zoya, de Moura, Alessandro Paula Servio, Valleriani, A., Zhang, G.   +12 more
core   +1 more source

Codon-by-codon modulation of translational speed and accuracy via mRNA folding. [PDF]

PLoS Biology, 2014
Rapid cell growth demands fast protein translational elongation to alleviate ribosome shortage. However, speedy elongation undermines translational accuracy because of a mechanistic tradeoff.
Jian-Rong Yang, Xiaoshu Chen, Jianzhi Zhang   +2 more
doaj   +1 more source

Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]

, 2013
Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias.
Kazana, Eleanna, von der Haar, Tobias, Bellanger, Noémie, Singh, Tarun, Chu, Dominique, Tuite, Mick F.   +5 more
core   +1 more source

Positive selection for unpreferred codon usage in eukaryotic genomes

BMC Evolutionary Biology, 2007
Background Natural selection has traditionally been understood as a force responsible for pushing genes to states of higher translational efficiency, whereas lower translational efficiency has been explained by neutral mutation and genetic drift.
Galagan James E, Neafsey Daniel E
doaj   +1 more source

Selective mRNA translation in erythropoiesis

Biochemical Society Transactions, 2015
The daily production of up to 1011 erythrocytes is tightly controlled to maintain the number of erythrocytes in peripheral blood between narrow boundaries. Availability of growth factors and nutrients, particularly iron, control the proliferation and survival of precursor cells partly through control of mRNA translation.
Thiadens, Klaske A. M. H., von Lindern, Marieke   +1 more
openaire   +2 more sources

Post-Translational Membrane Protein Targeting by the Chloroplast Signal Recognition Particle [PDF]

, 2011
Post-translational transport of membrane proteins poses enormous challenges to the cells. The transport factors must accurately select and deliver the cargos to the appropriate target membranes.
Jaru-Ampornpan, Peera
core   +1 more source

A blueprint for translational regenerative medicine [PDF]

, 2020
The last few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions to ...
Stuckey, D, Forbes, Stuart, Oreffo, Richard O. C., Oreffo, ROC, Armstrong, JPK, Forbes, Stuart J., Watt, FM, Stuckey, Daniel, Oreffo, Richard O.C., Barker, Roger A, Keane, Timothy, Stevens, Molly M, Roques, AC, Armstrong, James P.K., Mooney, CM, Armstrong, James, Pisupati, Venkat, Stevens, Molly M., Stephen Patrick, P, Patrick, P., Patrick, P. Stephen, Roques, A., Roques, Anne C., Stevens, Molly, Mooney, Claire M., Kuan, Wei-Li, Stevens, MM, Kuan, W-L, Keane, TJ, Pisupati, V, Stuckey, DJ, Kuan, Wei Li, Patrick, PS, Oreffo, Richard, Barker, Roger A., Barker, Roger, Watt, Fiona M, Watt, Fiona M., Barker, RA, Keane, Timothy J., Stuckey, Daniel J., Forbes, SJ, Mooney, Claire   +42 more
core   +1 more source

The Evolutionary Basis of Translational Accuracy in Plants

G3: Genes, Genomes, Genetics, 2017
Mistranslation errors compromise fitness by wasting resources on nonfunctional proteins. In order to reduce the cost of mistranslations, natural selection chooses the most accurately translated codons at sites that are particularly important for protein ...
Salvatore Camiolo, Gaurav Sablok, Andrea Porceddu   +2 more
doaj   +1 more source

Accounting for Programmed Ribosomal Frameshifting in the Computation of Codon Usage Bias Indices

G3: Genes, Genomes, Genetics, 2018
Experimental evidence shows that synonymous mutations can have important consequences on genetic fitness. Many organisms display codon usage bias (CUB), where synonymous codons that are translated into the same amino acid appear with distinct frequency ...
Victor Garcia, Stefan Zoller, Maria Anisimova   +2 more
doaj   +1 more source

Stops making sense: translational trade-offs and stop codon reassignment [PDF]

, 2011
Background Efficient gene expression involves a trade-off between (i) premature termination of protein synthesis; and (ii) readthrough, where the ribosome fails to dissociate at the terminal stop. Sense codons that are similar in sequence to stop codons
Steven C Le Comber, Johnson, Louise J, Johnson, LJ, Le Comber Steven C, Nichols Richard A, Louise J Johnson, Polly, PD, Lichtenstein, CP, Polly p David, Cotton, James A., Le Comber, SC, p David Polly, Le Comber, Steven C., Conrad P Lichtenstein, Cotton, JA, Nichols, RA, Lichtenstein Conrad P, James A Cotton, Elgar, GS, Elgar, Greg S., Lichtenstein, Conrad P., Elgar Greg S, Nichols, Richard A., Greg S Elgar, Cotton James A, Johnson Louise J, Johnson, Louise J., Richard A Nichols, Polly, P. David   +28 more
core   +1 more source