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UMCCTS Newsletter, March 2023 [PDF]
, 2023 This is the March 2023 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grants
UMass Center for Clinical and Translational Science
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Differences in codon bias cannot explain differences in translational power among microbes
BMC Bioinformatics, 2005 Background Translational power is the cellular rate of protein synthesis normalized to the biomass invested in translational machinery. Published data suggest a previously unrecognized pattern: translational power is higher among rapidly growing microbes,
Dethlefsen Les, Schmidt Thomas M
doaj +1 more source
UMCCTS Newsletter, October 2023 [PDF]
, 2023 This is the October 2023 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through ...
UMass Center for Clinical and Translational Science
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Genome Biology, 2018 Background Most amino acids are encoded by multiple synonymous codons. However, synonymous codons are not used equally, and this biased codon use varies between different organisms.
Emily A. Seward, Steven Kelly
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Selection against spurious promoter motifs correlates with translational efficiency across bacteria. [PDF]
PLoS ONE, 2007 Because binding of RNAP to misplaced sites could compromise the efficiency of transcription, natural selection for the optimization of gene expression should regulate the distribution of DNA motifs capable of RNAP-binding across the genome.
Jeffrey L Froula, M Pilar Francino
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Genome-wide analysis of codon usage bias in four sequenced cotton species. [PDF]
PLoS ONE, 2018 Codon usage bias (CUB) is an important evolutionary feature in a genome which provides important information for studying organism evolution, gene function and exogenous gene expression.
Liyuan Wang +9 more
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BMC Research Notes, 2018 Objective The purpose of this project was to use an in vivo method to discover riboswitches that are activated by new ligands. We employed phage-assisted continuous evolution (PACE) to evolve new riboswitches in vivo.
Zachary M. Shaver +30 more
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Discovery of indole-modified aptamers for highly specific recognition of protein glycoforms
Nature Communications, 2021 Glycosylation is an abundant form of post-translational modification. Here the authors present a generalizable workflow for the selection of indole-modified aptamers that can recognize protein glycoforms with high specificity.
Alex M. Yoshikawa +10 more
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Variation and selection on codon usage bias across an entire subphylum.
PLoS Genetics, 2019 Variation in synonymous codon usage is abundant across multiple levels of organization: between codons of an amino acid, between genes in a genome, and between genomes of different species.
Abigail L LaBella +4 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Transitioning from pediatric to adult care is a high‐risk period for individuals with sickle cell disease (SCD). An initial observation at one academic medical center suggested a sex‐based disparity in clinic populations, prompting a national investigation.
Laurie J. Duckworth +5 more
wiley +1 more source