Results 21 to 30 of about 396,222 (280)
A slight mismatch between a gene’s codon usage and the cellular tRNA supply is beneficial [PDF]
Nature CommunicationsEach amino acid except two is encoded by multiple synonymous codons, but at unequal frequencies. Such codon usage bias (CUB) is observable in almost all species, and commonly assumed as the result of natural selection towards an optimal CUB that matches ...
Feng Chen +8 more
doaj +2 more sources
Biomedical informatics and translational medicine [PDF]
Journal of Translational Medicine, 2010 Biomedical informatics involves a core set of methodologies that can provide a foundation for crossing the "translational barriers" associated with translational medicine.
Sarkar Indra
doaj +2 more sources
Pangenome Evidence for Higher Codon Usage Bias and Stronger Translational Selection in Core Genes of Escherichia coli [PDF]
Frontiers in Microbiology, 2016 Shixiang Sun +2 more
exaly +2 more sources
Translational Selection for Speed Is Not Sufficient to Explain Variation in Bacterial Codon Usage Bias. [PDF]
Genome Biol Evol, 2018 Increasing growth rate across bacteria strengthens selection for faster translation, concomitantly increasing the total number of tRNA genes and codon usage bias (CUB: enrichment of specific synonymous codons in highly expressed genes).
Mahajan S, Agashe D.
europepmc +2 more sources
BioTechniques, 2007 We have developed a novel vector, pTCS, as a tool for efficient selection of open reading frame (ORF)-containing inserts. In pTCS clones containing an insert with an ORF, a downstream marker gene (immE3, conferring resistance to colicin) is activated via
Sumiko Ohashi-Kunihiro +3 more
doaj +2 more sources
Strand-Specific Patterns of Codon Usage Bias Across Cressdnaviricota
Frontiers in Virology, 2022 The rapidly expanding phylum Cressdnaviricota contains circular, Rep-encoding single-stranded (CRESS) DNA viruses that are organized within seven established families, but many CRESS DNA virus sequences are not taxonomically defined. We hypothesized that
Alvin Crespo-Bellido, Siobain Duffy
doaj +1 more source
gtAI: an improved species-specific tRNA adaptation index using the genetic algorithm
Frontiers in Molecular Biosciences, 2023 The tRNA adaptation index (tAI) is a translation efficiency metric that considers weighted values (Sij values) for codon–tRNA wobble interaction efficiencies. The initial implementation of the tAI had significant flaws.
Ali Mostafa Anwar +9 more
doaj +1 more source
Ken Liu’s subjectivity in the English translation of “Santi” from the perspective of Eco-translatology [PDF]
Studia Translatorica, 2022 “The Three-Body Problem”, English version of the Chinese novel “Santi”, is the first translated novel to have received “Hugo Award for Best Novel”, the world’s best laurel for science fiction.
Chongyue Li, Xiangmei Chen
doaj +1 more source
BMC Microbiology, 2023 Introduction Whole genome sequencing (WGS) of bacterial isolates can be used to identify antimicrobial resistance (AMR) genes. Previous studies have shown that genotype-based AMR has variable accuracy for predicting carbapenem resistance in carbapenem ...
Rebecca Rose +12 more
doaj +1 more source
Learning to select a good translation [PDF]
Proceedings of the 18th conference on Computational linguistics -, 2000 Within the machine translation system Verbmobil, translation is performed simultaneously by four independent translation modules. The four competing translations are combined by a selection module so as to form a single optimal output for each input utterance. The selection module relies on confidence values that are delivered together with each of the
Dan Tidhar, Uwe Küssner
openaire +2 more sources