Translational selection is ubiquitous in prokaryotes. [PDF]
PLoS Genetics, 2010 Codon usage bias in prokaryotic genomes is largely a consequence of background substitution patterns in DNA, but highly expressed genes may show a preference towards codons that enable more efficient and/or accurate translation.
Fran Supek +4 more
doaj +8 more sources
Translational selection on SHH genes [PDF]
Genetics and Molecular Biology, 2010 Codon usage bias has been observed in various organisms. In this study, the correlation between SHH genes expression in some tissues and codon usage features was analyzed by bioinformatics.
Mohammadreza Hajjari +2 more
doaj +8 more sources
Base Composition and Translational Selection are Insufficient to Explain Codon Usage Bias in Plant Viruses [PDF]
Viruses, 2013 Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases.
Siobain Duffy +2 more
doaj +5 more sources
scnRCA: a novel method to detect consistent patterns of translational selection in mutationally-biased genomes. [PDF]
PLoS ONE, 2013 Codon usage bias (CUB) results from the complex interplay between translational selection and mutational biases. Current methods for CUB analysis apply heuristics to integrate both components, limiting the depth and scope of CUB analysis as a technique ...
Patrick K O'Neill, Mindy Or, Ivan Erill
doaj +5 more sources
Translational selection in human: more pronounced in housekeeping genes [PDF]
Biology Direct, 2014 Background: Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular eukaryotes. Recent evidence has shown that translational selection is weakly operative in highly expressed genes ...
Lina Ma
exaly +4 more sources
Contributions of speed and accuracy to translational selection in bacteria. [PDF]
PLoS ONE, 2012 Among bacteria, we have previously shown that species that are capable of rapid growth have stronger selection on codon usage than slow growing species, and possess higher numbers of rRNA and tRNA genes.
Wenqi Ran, Paul G Higgs
doaj +2 more sources
Estimating Translational Selection in Eukaryotic Genomes [PDF]
Molecular Biology and Evolution, 2008 Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the selection coefficients involved are very small.
dos Reis, M, Wernisch, L
openaire +6 more sources
Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids [PDF]
BMC Genomics, 2008 Background Different proteins are required in widely different quantities to build a living cell. In most organisms, transcription control makes a major contribution to differential expression. This is not the case in trypanosomatids where most genes are
Horn David
doaj +2 more sources
463 What’s your problem? Methods for refining translational science challenges to create meaningful solutions [PDF]
Journal of Clinical and Translational ScienceObjectives/Goals: The Michigan Institute for Clinical & Health Research (MICHR) created an eight-phase adaptive Translational Science Framework to guide us in selecting and solving translational science problems.
Elizabeth LaPensee +3 more
doaj +2 more sources
Gynecological Cancers Translational, Research Implementation, and Harmonization: Gynecologic Cancer InterGroup Consensus and Still Open Questions [PDF]
Cells, 2019 In the era of personalized medicine, the introduction of translational studies in clinical trials has substantially increased their costs, but provides the possibility of improving the productivity of trials with a better selection of recruited patients.
Marina Bagnoli +19 more
doaj +2 more sources