Translational selection is ubiquitous in prokaryotes. [PDF]
PLoS Genetics, 2010 Codon usage bias in prokaryotic genomes is largely a consequence of background substitution patterns in DNA, but highly expressed genes may show a preference towards codons that enable more efficient and/or accurate translation.
Fran Supek +4 more
doaj +7 more sources
Translational selection on SHH genes [PDF]
Genetics and Molecular Biology, 2010 Codon usage bias has been observed in various organisms. In this study, the correlation between SHH genes expression in some tissues and codon usage features was analyzed by bioinformatics.
Mohammadreza Hajjari +2 more
doaj +7 more sources
Base Composition and Translational Selection are Insufficient to Explain Codon Usage Bias in Plant Viruses [PDF]
Viruses, 2013 Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases.
Siobain Duffy +2 more
doaj +4 more sources
Translational selection in human: more pronounced in housekeeping genes [PDF]
Biology Direct, 2014 Background: Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular eukaryotes. Recent evidence has shown that translational selection is weakly operative in highly expressed genes ...
Zhang Zhang
exaly +5 more sources
Estimating translational selection in eukaryotic genomes. [PDF]
Mol Biol Evol, 2009 Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the ...
dos Reis M, Wernisch L.
europepmc +9 more sources
Accounting for Programmed Ribosomal Frameshifting in the Computation of Codon Usage Bias Indices [PDF]
G3: Genes, Genomes, Genetics, 2018 Experimental evidence shows that synonymous mutations can have important consequences on genetic fitness. Many organisms display codon usage bias (CUB), where synonymous codons that are translated into the same amino acid appear with distinct frequency ...
Victor Garcia +2 more
doaj +3 more sources
Contributions of speed and accuracy to translational selection in bacteria. [PDF]
PLoS ONE, 2012 Among bacteria, we have previously shown that species that are capable of rapid growth have stronger selection on codon usage than slow growing species, and possess higher numbers of rRNA and tRNA genes.
Wenqi Ran, Paul G Higgs
doaj +2 more sources
scnRCA: a novel method to detect consistent patterns of translational selection in mutationally-biased genomes. [PDF]
PLoS ONE, 2013 Codon usage bias (CUB) results from the complex interplay between translational selection and mutational biases. Current methods for CUB analysis apply heuristics to integrate both components, limiting the depth and scope of CUB analysis as a technique ...
Patrick K O'Neill, Mindy Or, Ivan Erill
doaj +2 more sources
A slight mismatch between a gene’s codon usage and the cellular tRNA supply is beneficial [PDF]
Nature CommunicationsEach amino acid except two is encoded by multiple synonymous codons, but at unequal frequencies. Such codon usage bias (CUB) is observable in almost all species, and commonly assumed as the result of natural selection towards an optimal CUB that matches ...
Feng Chen +8 more
doaj +2 more sources
Codon usage bias and selective constraints in Gentianales mitogenomes [PDF]
BMC GenomicsMitochondrial genome evolution(MGE) in flowering plants is quasi-intertwined-dynamic. MGE is driven via mutational pressures, translational selection, and functional constraints.
Sara Getachew Amenu +5 more
doaj +2 more sources