Development of an Ex Vivo Organ Culture Technique to Evaluate Probiotic Utilization in IBD [PDF]
, 2016 The consistent technical and conceptual progress in the study of the microbiota has led novel impulse to the research for therapeutical application of probiotic bacteria in human pathologies, such as inflammatory bowel disease (IBD).
DELLE FAVE, Gianfranco +3 more
core +1 more source
Codon-by-codon modulation of translational speed and accuracy via mRNA folding. [PDF]
PLoS Biology, 2014 Rapid cell growth demands fast protein translational elongation to alleviate ribosome shortage. However, speedy elongation undermines translational accuracy because of a mechanistic tradeoff.
Jian-Rong Yang +2 more
doaj +1 more source
Positive selection for unpreferred codon usage in eukaryotic genomes
BMC Evolutionary Biology, 2007 Background Natural selection has traditionally been understood as a force responsible for pushing genes to states of higher translational efficiency, whereas lower translational efficiency has been explained by neutral mutation and genetic drift.
Galagan James E, Neafsey Daniel E
doaj +1 more source
Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]
, 2013 Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias.
Aitken +55 more
core +2 more sources
The Evolutionary Basis of Translational Accuracy in Plants
G3: Genes, Genomes, Genetics, 2017 Mistranslation errors compromise fitness by wasting resources on nonfunctional proteins. In order to reduce the cost of mistranslations, natural selection chooses the most accurately translated codons at sites that are particularly important for protein ...
Salvatore Camiolo +2 more
doaj +1 more source
Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab [PDF]
, 2015 Background: The aim of our study was to evaluate whether a panel of biomarkers, prospectively analysed might be able to predict patients' clinical outcome more accurately than RAS status alone.
Abouelkhair, KM +10 more
core +3 more sources
A spatial impedance controller for robotic manipulation [PDF]
, 1997 Mechanical impedance is the dynamic generalization of stiffness, and determines interactive behavior by definition. Although the argument for explicitly controlling impedance is strong, impedance control has had only a modest impact on robotic ...
Broenink, Jan F., Fasse, Ernest D.
core +2 more sources
Differences in codon bias cannot explain differences in translational power among microbes
BMC Bioinformatics, 2005 Background Translational power is the cellular rate of protein synthesis normalized to the biomass invested in translational machinery. Published data suggest a previously unrecognized pattern: translational power is higher among rapidly growing microbes,
Dethlefsen Les, Schmidt Thomas M
doaj +1 more source
Selection against spurious promoter motifs correlates with translational efficiency across bacteria. [PDF]
PLoS ONE, 2007 Because binding of RNAP to misplaced sites could compromise the efficiency of transcription, natural selection for the optimization of gene expression should regulate the distribution of DNA motifs capable of RNAP-binding across the genome.
Jeffrey L Froula, M Pilar Francino
doaj +1 more source
The management of a blood donor bitten by a snake [PDF]
, 2017 The worldwide burden of snakebite is high and venomous snakes are found in many regions of the world and are a threat to public health. In Italy, for instance, viper bites are an infrequent but not negligible event.
Catalano, Liviana +5 more
core +1 more source