Results 31 to 40 of about 3,061,365 (279)

Regulation of translation in haloarchaea: 5'- and 3'-UTRs are essential and have to functionally interact in vivo [PDF]

, 2009
Recently a first genome-wide analysis of translational regulation using prokaryotic species had been performed which revealed that regulation of translational efficiency plays an important role in haloarchaea.
Jörg Soppa, Brenneis, Mariam, Mariam Brenneis, Soppa, Jörg (Prof. Dr.), Brenneis Mariam, Soppa Jörg   +5 more
core   +1 more source

Positive selection for unpreferred codon usage in eukaryotic genomes

BMC Evolutionary Biology, 2007
Background Natural selection has traditionally been understood as a force responsible for pushing genes to states of higher translational efficiency, whereas lower translational efficiency has been explained by neutral mutation and genetic drift.
Galagan James E, Neafsey Daniel E
doaj   +1 more source

UMCCTS Newsletter, December 2023 [PDF]

, 2023
This is the December 2023 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through ...
UMass Center for Clinical and Translational Science
core   +1 more source

Codon-by-codon modulation of translational speed and accuracy via mRNA folding. [PDF]

PLoS Biology, 2014
Rapid cell growth demands fast protein translational elongation to alleviate ribosome shortage. However, speedy elongation undermines translational accuracy because of a mechanistic tradeoff.
Jian-Rong Yang, Xiaoshu Chen, Jianzhi Zhang   +2 more
doaj   +1 more source

Selective mRNA translation in erythropoiesis

Biochemical Society Transactions, 2015
The daily production of up to 1011 erythrocytes is tightly controlled to maintain the number of erythrocytes in peripheral blood between narrow boundaries. Availability of growth factors and nutrients, particularly iron, control the proliferation and survival of precursor cells partly through control of mRNA translation.
Thiadens, Klaske A. M. H., von Lindern, Marieke   +1 more
openaire   +2 more sources

The Evolutionary Basis of Translational Accuracy in Plants

G3: Genes, Genomes, Genetics, 2017
Mistranslation errors compromise fitness by wasting resources on nonfunctional proteins. In order to reduce the cost of mistranslations, natural selection chooses the most accurately translated codons at sites that are particularly important for protein ...
Salvatore Camiolo, Gaurav Sablok, Andrea Porceddu   +2 more
doaj   +1 more source

Genome-wide analysis of growth phase-dependent translational and transcriptional regulation in halophilic archaea : research article [PDF]

, 2007
Background Differential expression of genes can be regulated on many different levels. Most global studies of gene regulation concentrate on transcript level regulation, and very few global analyses of differential translational efficiencies exist.
Schuster Stephan C, Lange, Christian, Oesterhelt, Dieter, Raddatz, Günter, Dieter Oesterhelt, Soppa, Jörg (Prof. Dr.), Jens Twellmeyer, Christian Lange, Soppa Jörg, Twellmeyer, Jens, Zaigler, Alexander, Oesterhelt Dieter, Jörg Soppa, Günter Raddatz, Lange, C., Raddatz Günter, Zaigler Alexander, Soppa, J., Lange Christian, Schuster, S., Zaigler, A., Schuster, Stephan C., Alexander Zaigler, Oesterhelt, D., Hammelmann Mathias, Raddatz, G., Stephan C Schuster, Mathias Hammelmann, Hammelmann, Mathias, Twellmeyer Jens, Hammelmann, M., Twellmeyer, J.   +31 more
core   +1 more source

UMCCTS Newsletter, June 2023 [PDF]

, 2023
This is the June 2023 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grants ...
UMass Center for Clinical and Translational Science
core   +1 more source

Accounting for Programmed Ribosomal Frameshifting in the Computation of Codon Usage Bias Indices

G3: Genes, Genomes, Genetics, 2018
Experimental evidence shows that synonymous mutations can have important consequences on genetic fitness. Many organisms display codon usage bias (CUB), where synonymous codons that are translated into the same amino acid appear with distinct frequency ...
Victor Garcia, Stefan Zoller, Maria Anisimova   +2 more
doaj   +1 more source

A quantitative estimation of the global translational activity in logarithmically growing yeast cells. [PDF]

, 2008
BACKGROUND: Translation of messenger mRNAs makes significant contributions to the control of gene expression in all eukaryotes. Because translational control often involves fractional changes in translational activity, good quantitative descriptions of ...
von der Haar, Tobias, Tobias von der Haar   +1 more
core   +1 more source