Results 31 to 40 of about 396,222 (280)

Development of a clinical and translational research curriculum for undergraduate students

Journal of Clinical and Translational Science, 2023
Introduction: Research participation during undergraduate years has a powerful influence on career selection and attitudes toward scientific research. Most undergraduate research programs in academic health centers are oriented toward basic research or ...
Laura James, Tara Venable, Andres Caro, Jeffrey H. Moran, Claire Nesmith, Matthew A. Gannon, Lawrence E. Cornett   +6 more
doaj   +1 more source

Recognition and selection of tRNA in translation [PDF]

FEBS Letters, 2004
Aminoacyl‐tRNA (aa‐tRNA) is delivered to the ribosome in a ternary complex with elongation factor Tu (EF‐Tu) and GTP. The stepwise movement of aa‐tRNA from EF‐Tu into the ribosomal A site entails a number of intermediates. The ribosome recognizes aa‐tRNA through shape discrimination of the codon–anticodon duplex and regulates the rates of GTP ...
Rodnina, M., Gromadski, K., Kothe, U., Wieden, H.   +3 more
openaire   +4 more sources

The Translator’s Adaptation and Selection in the Approach to Translation as Adaptation and Selection

Pacific International Journal, 2023
San Zi Jing, with short form, pleasing rhythm and profound significance, is a well-known and representative classic among ancient enlightenment children’s books in traditional Chinese society. The core of Translation as Adaptation and Selection is the translator’s adaptation to the translational eco-environment of the original text and the ...
openaire   +1 more source

Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine

Frontiers in Cellular and Infection Microbiology, 2018
Live attenuated vaccines are widely used to protect humans or animals from pathogen infections. We have previously developed a chicken embryo-attenuated Duck Hepatitis A Virus genotype 1 (DHAV-1) vaccine (CH60 strain).
Xumin Ou, Xumin Ou, Xumin Ou, Mingshu Wang, Mingshu Wang, Mingshu Wang, Sai Mao, Sai Mao, Jingyu Cao, Jingyu Cao, Anchun Cheng, Anchun Cheng, Anchun Cheng, Dekang Zhu, Dekang Zhu, Shun Chen, Shun Chen, Shun Chen, Renyong Jia, Renyong Jia, Renyong Jia, Mafeng Liu, Mafeng Liu, Mafeng Liu, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Xiaoyue Chen, Xiaoyue Chen, Maikel P. Peppelenbosch, Qiuwei Pan   +48 more
doaj   +1 more source

Genome-wide analysis of growth phase-dependent translational and transcriptional regulation in halophilic archaea : research article [PDF]

, 2007
Background Differential expression of genes can be regulated on many different levels. Most global studies of gene regulation concentrate on transcript level regulation, and very few global analyses of differential translational efficiencies exist.
Schuster Stephan C, Lange, Christian, Oesterhelt, Dieter, Raddatz, Günter, Dieter Oesterhelt, Soppa, Jörg (Prof. Dr.), Jens Twellmeyer, Christian Lange, Soppa Jörg, Twellmeyer, Jens, Zaigler, Alexander, Oesterhelt Dieter, Jörg Soppa, Günter Raddatz, Lange, C., Raddatz Günter, Zaigler Alexander, Soppa, J., Lange Christian, Schuster, S., Zaigler, A., Schuster, Stephan C., Alexander Zaigler, Oesterhelt, D., Hammelmann Mathias, Raddatz, G., Stephan C Schuster, Mathias Hammelmann, Hammelmann, Mathias, Twellmeyer Jens, Hammelmann, M., Twellmeyer, J.   +31 more
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Analysis of factors shaping synonymous codon usage in pseudorabies virus

浙江大学学报. 农业与生命科学版, 2007
Synonymous codon usage and the main factors shaping codon usage in pseudorabies virus were reported in order to understand the architecture and evolution of pseudorabies virus.
YIN Hua-ping, GUO Wan-zhu, XU Zhi-wen, YANG Li   +3 more
doaj   +1 more source

A quantitative estimation of the global translational activity in logarithmically growing yeast cells. [PDF]

, 2008
BACKGROUND: Translation of messenger mRNAs makes significant contributions to the control of gene expression in all eukaryotes. Because translational control often involves fractional changes in translational activity, good quantitative descriptions of ...
von der Haar, Tobias, Tobias von der Haar   +1 more
core   +1 more source

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Nature Communications, 2020
Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models.
Elizabeth A. Killion, Michelle Chen, James R. Falsey, Glenn Sivits, Todd Hager, Larissa Atangan, Joan Helmering, Jae Lee, Hongyan Li, Bin Wu, Yuan Cheng, Murielle M. Véniant, David J. Lloyd   +12 more
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Balanced codon usage optimizes eukaryotic translational efficiency. [PDF]

PLoS Genetics, 2012
Cellular efficiency in protein translation is an important fitness determinant in rapidly growing organisms. It is widely believed that synonymous codons are translated with unequal speeds and that translational efficiency is maximized by the exclusive ...
Wenfeng Qian, Jian-Rong Yang, Nathaniel M Pearson, Calum Maclean, Jianzhi Zhang   +4 more
doaj   +1 more source

Recombination, meiotic expression and human codon usage

eLife, 2017
Synonymous codon usage (SCU) varies widely among human genes. In particular, genes involved in different functional categories display a distinct codon usage, which was interpreted as evidence that SCU is adaptively constrained to optimize translation ...
Fanny Pouyet, Dominique Mouchiroud, Laurent Duret, Marie Sémon   +3 more
doaj   +1 more source