Results 71 to 80 of about 687,731 (280)

Statistical competencies for medical research learners: What is fundamental? [PDF]

, 2017
IntroductionIt is increasingly essential for medical researchers to be literate in statistics, but the requisite degree of literacy is not the same for every statistical competency in translational research.
Benn, Emma KT, Carter, Rickey E, Enders, Felicity T, Grambow, Steven C, Kidwell, Kelley M, Larson, Joseph, Lindsell, Christopher J, Mayo, Matthew S, Oster, Robert A, Perkins, Susan M, Pollock, Brad H, Rahbar, Mohammad H, Spratt, Heidi, Thurston, Sally W, Welty, Leah J   +14 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Generic decoupled image-based visual servoing for cameras obeying the unified projection model [PDF]

, 2009
In this paper a generic decoupled imaged-based control scheme for calibrated cameras obeying the unified projection model is proposed. The proposed decoupled scheme is based on the surface of object projections onto the unit sphere.
François Chaumette, Omar Tahri, Peter Corke, Senior Member, Youcef Mezouar   +4 more
core   +10 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Gynecological Cancers Translational, Research Implementation, and Harmonization: Gynecologic Cancer InterGroup Consensus and Still Open Questions

Cells, 2019
In the era of personalized medicine, the introduction of translational studies in clinical trials has substantially increased their costs, but provides the possibility of improving the productivity of trials with a better selection of recruited patients.
Marina Bagnoli, Ting Yan Shi, Charlie Gourley, Paul Speiser, Alexander Reuss, Hans W. Nijman, Carien L. Creutzberg, Suzy Scholl, Anastassia Negrouk, Mark F. Brady, Kosei Hasegawa, Katsutoshi Oda, Iain A. McNeish, Elise C. Kohn, Amit M. Oza, Helen MacKay, David Millan, Katherine Bennett, Clare Scott, Delia Mezzanzanica   +19 more
doaj   +1 more source

Emergence of Approximate Translation Invariance in Finite Intervals as a Speed Selection Mechanism for Propagating Fronts

, 2000
We introduce a new velocity selection criterion for fronts propagating into unstable and metastable states. We restrict these fronts to large finite intervals in the comoving frame of reference and require their centers be insensitive to the locations of
Leontidis, Epameinondas, Theodorakis, Stavros   +1 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

463 What’s your problem? Methods for refining translational science challenges to create meaningful solutions

Journal of Clinical and Translational Science
Objectives/Goals: The Michigan Institute for Clinical & Health Research (MICHR) created an eight-phase adaptive Translational Science Framework to guide us in selecting and solving translational science problems.
Elizabeth LaPensee, Maureen Brudzinski, Sarah Miles, Elias Samuels   +3 more
doaj   +1 more source

Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids

BMC Genomics, 2008
Background Different proteins are required in widely different quantities to build a living cell. In most organisms, transcription control makes a major contribution to differential expression. This is not the case in trypanosomatids where most genes are
Horn David
doaj   +1 more source

Environmental shaping of codon usage and functional adaptation across microbial communities. [PDF]

, 2013
Microbial communities represent the largest portion of the Earth's biomass. Metagenomics projects use high-throughput sequencing to survey these communities and shed light on genetic capabilities that enable microbes to inhabit every corner of the ...
Achtman, Altschul, Arumugam, Boto, Botzman, Bruggemann, Burke, Caro-Quintero, Chen, Diene, Donner, Foerstner, Forsberg, Gill, Hershberg, Horvath, Hunyadkurti, Huson, Ikemura, István Nagy, Jensen, Johnson, Kanaya, Kanehisa, Karlin, Keeling, Keller, Kristian Vlahoviček, Kuo, Larimer, Malmstrom, Martin, Maša Roller, McDaniel, McDowell, Mira, Myers, Oda, Plotkin, R Development Core Team, Retchless, Rocha, Sharp, Sharp, Sowell, Staley, Supek, Supek, Tatusov, Tettelin, Tina Perica, Tringe, Tuller, Tuller, Tuller, Turnbaugh, Tyson, Vedran Lucić, Venter, Verberkmoes, Vieira-Silva, Whitman, Willenbrock, Wilmes   +63 more
core   +1 more source