Results 81 to 90 of about 687,731 (280)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Decoding CMOS Rolling-Shutter Pattern in Translational or Rotational Motions for VLC

IEEE Photonics Journal, 2019
We propose and demonstrate a CMOS rolling-shutter pattern decoding scheme based on two newly introduced schemes, named row grayscale redistribution and differential grayscale packet selection to improve the performance in decoding the CMOS rolling ...
Chi-Wai Chow, Zhi-Qing Li, Yu-Cheng Chuang, Xin-Lan Liao, Kun-Hsien Lin, Yi-Yuan Chen   +5 more
doaj   +1 more source

Stochastic theory of protein synthesis and polysome: ribosome profile on a single mRNA transcript

, 2011
The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called {\it translation}. Ribosome may be regarded as a molecular motor for which the mRNA template serves also as the track.
Agirrezabala, Ajeet K. Sharma, Alberts, Antal, Arava, Arava, Basu, Chou, Chou, Chowdhury, Chowdhury, Ciandrini, Debashish Chowdhury, Derrida, Frank, Garai, Gilchrist, Guo, Hager, Hager, Harrington, Hirokawa, Hopfield, Ingolia, Kolomeisky, Krug, Lakatos, Lodish, MacDonald, MacDonald, Mikamo, Mukamel, Ninio, Noll, Popkov, Reynolds, Rich, Romero, Schadschneider, Schütz, Sharma, Sharma, Shaw, Shaw, Shaw, Spirin, Spirin, Thompson, Warner, Warner, Zhdanov, Zia, Zouridis   +52 more
core   +1 more source

Depression and suicide risk prediction models using blood-derived multi-omics data [PDF]

, 2019
More than 300 million people worldwide experience depression; annually, ~800,000 people die by suicide. Unfortunately, conventional interview-based diagnosis is insufficient to accurately predict a psychiatric status. We developed machine learning models
Bhak, Jong, Bhak, Youngjune, Blazyte, Asta, Cho, Juok, Cho, Yun Sung, Gim, Jeong-An, Ham, Byung-Joo, Jeon, Sungwon, Jeon, Yeonsu, Jeong, Hyoung-oh, Kang, Wooyoung, Kim, Aram, Kim, Byung Chul, Kim, Hak-Min, Kim, Yumi, Lee, Hae-Woo, Lee, Semin, Paik, Jong-Woo, Park, Seung Gu, Shin, Eun-Seok   +19 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The surviving sepsis campaign: basic/translational science research priorities

Intensive Care Medicine Experimental, 2020
Objectives Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.
Clifford S. Deutschman, Judith Hellman, Ricard Ferrer Roca, Daniel De Backer, Craig M. Coopersmith, for the Research Committee of the Surviving Sepsis Campaign   +5 more
doaj   +1 more source

Admittance Selection for Force-guided Assembly of Polyhedral Parts in Single-point Contact [PDF]

, 2004
The selection of the proper admittance is important in achieving force-guided assembly. This paper identifies procedures for selecting the appropriate spatial admittance to achieve reliable force-guided assembly of polyhedral parts for single-point ...
Huang, Shuguang, Schimmels, Joseph M.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Neuroimaging as a selection tool and endpoint in preclinical and clinical trials [PDF]

, 2016
Standard imaging in acute stroke enables the exclusion of non-stroke structural CNS lesions and cerebral haemorrhage from clinical and pre-clinical ischaemic stroke trials. In this review, the potential benefit of imaging (e.g., angiography and penumbral
Macrae, I. Mhairi, Muir, Keith W.
core   +2 more sources