Results 91 to 100 of about 687,731 (280)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Journal of Clinical and Translational Science, 2017 Introduction Previous studies have examined the impact of Clinical and Translational Science Awards programs on other outcomes, but not on grant seeking. The authors examined the effects on grant seeking of the
Felichism W. Kabo, George A. Mashour
doaj +1 more source
Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major [PDF]
, 2019 Besides their medical relevance, Leishmania is an adequate model for studying post-transcriptional mechanisms of gene expression. In this microorganism, mRNA degradation/stabilization mechanisms together with translational control and post-translational ...
Aguado, Begoña +5 more
core +2 more sources
Lexical selection for machine translation.
, 2011 Current research in Natural Language Processing (NLP) tends to exploit corpus resources as a way of overcoming the problem of knowledge acquisition. Statistical analysis of corpora can reveal trends and probabilities of occurrence, which have proved to be helpful in various ways. Machine Translation (MT) is no exception to this trend.
openaire +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Fingerprints for spin-selection rules in the interaction dynamics of O2 at Al(111)
, 2008 We performed mixed quantum-classical molecular dynamics simulations based on first-principles potential-energy surfaces to demonstrate that the scattering of a beam of singlet O2 molecules at Al(111) will enable an unambiguous assessment of the role of ...
Axel Groß +4 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
PLoS Computational Biology, 2018 Translation of consecutive prolines causes ribosome stalling, which is alleviated but cannot be fully compensated by the elongation factor P. However, the presence of polyproline motifs in about one third of the E.
Fei Qi +4 more
doaj +1 more source
Molecular evolution of synonymous codon usage in
BMC Evolutionary Biology, 2008 Background Evolution of synonymous codon usage is thought to be determined by a balance between mutation, genetic drift and natural selection on translational efficiency.
Ingvarsson Pär K
doaj +1 more source
Control of ribosome traffic by position-dependent choice of synonymous codons
, 2013 Messenger RNA encodes a sequence of amino acids by using codons. For most amino acids there are multiple synonymous codons that can encode the amino acid.
Mitarai, Namiko, Pedersen, Steen
core +1 more source