Results 91 to 100 of about 3,061,365 (279)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

UMCCTS Newsletter, November 2024 [PDF]

This is the Novembr 2024 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through ...
UMass Center for Clinical and Translational Science
core   +1 more source

Codon usage bias and selective constraints in Gentianales mitogenomes

BMC Genomics
Mitochondrial genome evolution(MGE) in flowering plants is quasi-intertwined-dynamic. MGE is driven via mutational pressures, translational selection, and functional constraints.
Sara Getachew Amenu, Liao Yiying, Oyetola Oyebanji, Girma Eshetu, Ann Wanjiru Mwaniki, Wan Tao   +5 more
doaj   +1 more source

A Comment on: “Lip reconstruction using superficial flaps: functional and aesthetic integration” [PDF]

Surgical & Cosmetic Dermatology
This Letter to the Editor comments on the article “Lip reconstruction using superficial flaps: functional and aesthetic integration.” The reported case series provides valuable clinical examples of individualized superficial flap selection for upper and ...
Muhammed Said Aydin, Gökay Özler
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

UMCCTS Newsletter, May 2025 [PDF]

This is the May 2025 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grants ...
UMass Center for Clinical and Translational Science
core   +1 more source

A slight mismatch between a gene’s codon usage and the cellular tRNA supply is beneficial

Nature Communications
Each amino acid except two is encoded by multiple synonymous codons, but at unequal frequencies. Such codon usage bias (CUB) is observable in almost all species, and commonly assumed as the result of natural selection towards an optimal CUB that matches ...
Feng Chen, Yao Liu, Ziwei Zhou, Jia Liao, Xinran Fan, Yanying Huang, Yifei Chen, Jingyu Chen, Jian-Rong Yang   +8 more
doaj   +1 more source

Evolutionary analysis of polyproline motifs in Escherichia coli reveals their regulatory role in translation.

PLoS Computational Biology, 2018
Translation of consecutive prolines causes ribosome stalling, which is alleviated but cannot be fully compensated by the elongation factor P. However, the presence of polyproline motifs in about one third of the E.
Fei Qi, Magdalena Motz, Kirsten Jung, Jürgen Lassak, Dmitrij Frishman   +4 more
doaj   +1 more source

Molecular evolution of synonymous codon usage in Populus

BMC Evolutionary Biology, 2008
Background Evolution of synonymous codon usage is thought to be determined by a balance between mutation, genetic drift and natural selection on translational efficiency.
Ingvarsson Pär K
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source