Results 121 to 130 of about 5,654 (195)
Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus [PDF]
, 2017 Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs).
Berciano, Maria T. +7 more
core +2 more sources
RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress
BMC Genomics, 2019 Background Aging is accompanied with loss of tissue homeostasis and accumulation of cellular damages. As one of the important metabolic centers, liver shows age-related dysregulation of lipid metabolism, impaired detoxification pathway, increased ...
Kerui Huang +5 more
doaj +1 more source
Positional proteomics reveals differences in N-terminal proteoform stability [PDF]
, 2016 To understand the impact of alternative translation initiation on a proteome, we performed a proteome-wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes.
Brown JL +4 more
core +2 more sources
Post-transcriptional regulation in the myo1Δ mutant of Saccharomyces cerevisiae [PDF]
, 2010 Background Saccharomyces cerevisiae myosin type II-deficient (myo1 Δ) strains remain viable and divide, despite the absence of a cytokinetic ring, by activation of the PKC1-dependent cell wall integrity pathway (CWIP).
Marielis E Rivera-Ruiz +3 more
core +1 more source
Correction: Stress-Dependent Coordination of Transcriptome and Translatome in Yeast
PLoS Biology, 2012 The column headings in Dataset S3 are incorrect due to a formatting error. The Column headings in Columns K-P were originally presented in an incorrect order. Please view the correct Dataset S3 here: Click here for additional data file.(368K, xls)
Regula E Halbeisen, André P Gerber
openaire +2 more sources
Proteogenomics in aid of host-pathogen interaction studies : a bacterial perspective [PDF]
, 2017 By providing useful tools to study host-pathogen interactions, next-generation omics has recently enabled the study of gene expression changes in both pathogen and infected host simultaneously.
Fels, Ursula +2 more
core +3 more sources
Nature Communications, 2016 Bacteria of the genus Streptomyces produce a great variety of natural products, the biosynthesis of which is subject to complex regulatory networks. Here the authors present a high-resolution, genome-wide analysis of the transcriptome and translatome of ...
Yujin Jeong +10 more
doaj +1 more source
Isolating and Characterizing the Translatome From Human Alzheimer's Disease (AD) Brains
BJPsych OpenAims Local protein synthesis at the synapse is a key determinant of learning and memory and is predicted to be severely disrupted in Alzheimer's disease (AD).
Muhammad Ali Bangash, Julie Qiaojin Lin
doaj +1 more source
Scientific Reports, 2017 The epidemic of obesity and diabetes has markedly spurred the research interest in adipocyte biology. Brown adipocytes are specialized for energy expenditure and of therapeutic interest for treatment of metabolic diseases, but how brown adipocytes are ...
David W. Reid +4 more
doaj +1 more source