Results 101 to 110 of about 5,654 (195)

eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs [PDF]

, 2017
Alternative translation initiation mechanisms such as leaky scanning and reinitiation potentiate the polycistronic nature of human transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stimuli.
Fijalkowska, Daria, Jonckheere, Veronique, Menschaert, Gerben, Ndah, Elvis, Van Damme, Petra, Verbruggen, Steven   +5 more
core   +1 more source

Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. [PDF]

, 2019
Genome wide association studies (GWAS) in obesity have identified a large number of noncoding loci located near genes expressed in the central nervous system.
Ahituv, Nadav, Eckalbar, Walter L, Inoue, Fumitaka, Matharu, Navneet, Murphy, Karl K, Vaisse, Christian, Wang, Yi   +6 more
core   +1 more source

Quantitative Insights into the Genetic Mechanisms of Crop Heterosis

Advanced Genetics, Volume 6, Issue 4, December 2025.
Inheritance patterns of genomics‐downstream molecules, including transcripts, proteins, and metabolites, are analyzed in hybrid crops. The additive effect, which describes mid‐parent level, is a predominant inheritance pattern in crop heterosis and can be used to improve breeding efficiency of high‐yield hybrid varieties.
Zhiwu Dan, Yunping Chen, Wenchao Huang
wiley   +1 more source

Vesicular Rps6 Released by Astrocytes in an Experimental Model of AD Regulates Local Translation and Enhances Synaptic Integrity in Neurones

Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
ABSTRACT In neurones, like in any other cell, their function often relies on the fine‐tuning of their protein levels, which is achieved by the balance between protein synthesis and turnover. Defects in protein homeostasis frequently lead to neuronal dysfunction and neurological disorders.
María Gamarra, Aida de la Cruz‐Gambra, Maite Blanco‐Urrejola, Esperanza González, Mikel Azkargorta, Felix Elortza, Juan Manuel Falcón‐Pérez, Jimena Baleriola   +7 more
wiley   +1 more source

Effects of Kasugamycin on the Translatome of Escherichia coli

PLOS ONE, 2017
It is long known that Kasugamycin inhibits translation of canonical transcripts containing a 5'-UTR with a Shine Dalgarno (SD) motif, but not that of leaderless transcripts. To gain a global overview of the influence of Kasugamycin on translation efficiencies, the changes of the translatome of Escherichia coli induced by a 10 minutes Kasugamycin ...
Lange, Christian, Lehr, Matthias, Zerulla, Karolin, Ludwig, Pete, Schweitzer, Jens, Polen, Tino, Wendisch, Volker F., Soppa, Jörg   +7 more
openaire   +8 more sources

A translational program that suppresses metabolism to shield the genome

Nature Communications, 2020
Translatome remodelling controls stress-adaptive protein output. Here the authors reveal that in response to stimuli, eIF5A functions as a pH-regulated translation factor that responds to fermentation-induced acidosis affecting cellular metabolism.
Nathan C. Balukoff, J. J. David Ho, Phaedra R. Theodoridis, Miling Wang, Michael Bokros, Lis M. Llanio, Jonathan R. Krieger, Jonathan H. Schatz, Stephen Lee   +8 more
doaj   +1 more source

Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice

Molecular Metabolism, 2020
Objective: Maternal unbalanced nutritional habits during embryonic development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing obesity-associated diabetes risk. However, the underlying molecular mechanisms
Roberta Haddad-Tóvolli, Jordi Altirriba, Arnaud Obri, Elena Eyre Sánchez, Iñigo Chivite, Maria Milà-Guasch, Sara Ramírez, Alicia G. Gómez-Valadés, Macarena Pozo, Jasmine Burguet, Licio A. Velloso, Marc Claret   +11 more
doaj   +1 more source

eIF4A inhibitors suppress cell-cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer [PDF]

, 2019
CDK4/6 inhibitors are FDA-approved drugs for estrogen receptor-positive (ER+) breast cancer and are being evaluated to treat other tumor types, including KRAS-mutant non-small cell lung cancer (NSCLC).
Cencic, Regina, Foulkes, William D., Fu, Zheng, Guiot, Marie-Christine, Huang, Sidong, Kong, Tim, Monast, Anie, Park, Morag, Pelletier, Jerry, Pilon, Virginie, Porco, John A., Sangwan, Veena, Xue, Yibo, Zhu, Xianbing   +13 more
core   +1 more source

Translational Remodeling of the Synaptic Proteome During Aging

Aging Cell, Volume 24, Issue 12, December 2025.
Aging induces a decoupling of protein regulation between the soma and the synapse. In particular, transcripts coding for ribosomal proteins decrease and their corresponding proteins increase in the synapse while the opposite happens in the soma. At the same time, synapse‐specific regulation of splicing takes place.
Cinzia Caterino, Martino Ugolini, William Durso, Kristina Jevdokimenko, Marco Groth, Konstantin Riege, Matthias Görlach, Eugenio Fornasiero, Alessandro Ori, Steve Hoffmann, Alessandro Cellerino   +10 more
wiley   +1 more source

Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum

Nature Communications, 2020
Striatal dopaminoceptive neurons are molecularly and functionally heterogeneous. Here, the authors provide the translatome of D2R striatal neurons and identified hundreds of region specific molecular markers as well as testing their resource to shed ...
Emma Puighermanal, Laia Castell, Anna Esteve-Codina, Su Melser, Konstantin Kaganovsky, Charleine Zussy, Jihane Boubaker-Vitre, Marta Gut, Stephanie Rialle, Christoph Kellendonk, Elisenda Sanz, Albert Quintana, Giovanni Marsicano, Miquel Martin, Marcelo Rubinstein, Jean-Antoine Girault, Jun B. Ding, Emmanuel Valjent   +17 more
doaj   +1 more source