Biological Insights into the Expression of Translation Initiation Factors from Recombinant CHOK1SV Cell Lines and their Relationship to Enhanced Productivity [PDF]
, 2015 Translation initiation is on the critical pathway for the production of monoclonal antibodies (mAb) by mammalian cells. Formation of a closed loop structure comprised of mRNA, a number of eukaryotic initiation factors and ribosomal proteins has been ...
Bahr +65 more
core +1 more source
Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.Abstract INTRODUCTION Circadian rhythm disruption is an early symptom of Alzheimer's disease (AD), though it remains unclear how the light‐dark (LD) cycle and the central circadian clock in the suprachiasmatic nucleus (SCN) influence AD pathobiology.
Melvin W. King +4 more
wiley +1 more source
Optimization of carbon and energy utilization through differential translational efficiency. [PDF]
, 2018 Control of translation is vital to all species. Here we employ a multi-omics approach to decipher condition-dependent translational regulation in the model acetogen Clostridium ljungdahlii.
Al-Bassam, Mahmoud M +7 more
core +2 more sources
Cellular decision-making bias: the missing ingredient in cell functional diversity
, 2013 Cell functional diversity is a significant determinant on how biological processes unfold. Most accounts of diversity involve a search for sequence or expression differences. Perhaps there are more subtle mechanisms at work.
Alicea, Bradly
core +2 more sources
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome [PDF]
, 2013 Ubiquitin-dependent proteolysis can initiate at ribosomes for myriad reasons including misfolding of a nascent chain or stalling of the ribosome during translation of mRNA.
Deshaies, Raymond J. +3 more
core +1 more source
Ribosome biogenesis and control of translation in cancer cells [PDF]
, 2017 Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia, Universitat de Barcelona, 2017. Tutor/a: Antonio Gentilella.[eng] Ribosomes are ribonucleoprotein complexes present in every cell type, their main function being the synthesis of proteins ...
Balvey Gil, Alexandra
core
Puf3p induces translational repression of genes linked to oxidative stress [PDF]
, 2013 In response to stress, the translation of many mRNAs in yeast can change in a fashion discordant with the general repression of translation. Here, we use machine learning to mine the properties of these mRNAs to determine specific translation control ...
Ashe, M.P. +8 more
core +1 more source
Hormone-Mediated Gene-Specific Translation Regulation [PDF]
, 2016 The central role of translation regulation in the control of critical cellular processes has long been recognized. Yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to specific stimuli has only ...
Alonso, José +4 more
core
Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]
, 2014 microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei +2 more
core +3 more sources
Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs [PDF]
, 2014 Hematopoietic stem cells (HSCs) are maintained through the regulation of symmetric and asymmetric cell division. We report that conditional ablation of the RNA-binding protein Msi2 results in a failure of HSC maintenance and engraftment caused by a loss ...
Al-Shahrour, Fatima +11 more
core +1 more source