Results 91 to 100 of about 5,654 (195)

PROTEOFORMER: deep proteome coverage through ribosome profiling and MS integration [PDF]

, 2014
An increasing amount of studies integrate mRNA sequencing data into MS-based proteomics to complement the translation product search space. However, several factors, including extensive regulation of mRNA translation and the need for three- or six-frame ...
Crappé, Jeroen, De Keulenaer, Sarah, De Meester, Ellen, De Meyer, Tim, Fijalkowska, Daria, Koch, Alexander, Menschaert, Gerben, Ndah, Elvis, Steyaert, Sandra, Van Criekinge, Wim, Van Damme, Petra   +10 more
core   +1 more source

Selective translational usage of TSS and core promoters revealed by translatome sequencing

BMC Genomics, 2019
Background In mammals, fine-tuned regulation of gene expression leads to transcription initiation from diverse transcription start sites (TSSs) and multiple core promoters. Although polysome association is a critical step in translation, whether polysome
Hua Li, Ling Bai, Hongmei Li, Xinhui Li, Yani Kang, Ningbo Zhang, Jielin Sun, Zhifeng Shao   +7 more
doaj   +1 more source

Generation of ribosome imprinted polymers for sensitive detection of translational responses [PDF]

, 2017
Whilst the profiling of the transcriptome and proteome even of single-cells becomes feasible, the analysis of the translatome, which refers to all messenger RNAs (mRNAs) engaged with ribosomes for protein synthesis, is still an elaborate procedure ...
A Martin-Esteban, AG Hinnebusch, AL Bole, AM Anger, AS Petrov, B Schwanhausser, C Vogel, CA Piccirillo, DM Hawkins, DM Hawkins, DR Kryscio, E Saridakis, E Shapiro, FS Fritzsch, G Vasapollo, HA King, HC Jeffery, HF El-Sharif, HF El-Sharif, JZ Hilt, KM Kuhn, L Chen, LD Bolisay, LD Bolisay, M Heiman, M Ledda, M Zayats, ME Zanetti, MJ Whitcombe, ML Truitt, MR Fabian, MW Pfaffl, N Terada, NT Ingolia, NT Ingolia, O Hayden, O Meyuhas, Q Tian, RE Halbeisen, RE Halbeisen, S Bursac, S Chunta, S Klinge, S Kuersten, SJ Li, SM Reddy, V Gandin, V Iadevaia, VJ Ruigrok, Y Liu, YJ Chen   +50 more
core   +1 more source

Translational control in plants: from basic mechanisms to environmental and developmental responses

The Plant Journal, Volume 125, Issue 1, January 2026.
SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons, Catharina Merchante, Anna N. Stepanova, Jose M. Alonso   +3 more
wiley   +1 more source

Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

eLife, 2019
Hypoxia, a major inducer of angiogenesis, triggers major changes in gene expression at the transcriptional level. Furthermore, under hypoxia, global protein synthesis is blocked while internal ribosome entry sites (IRES) allow specific mRNAs to be ...
Fransky Hantelys, Anne-Claire Godet, Florian David, Florence Tatin, Edith Renaud-Gabardos, Françoise Pujol, Leila H Diallo, Isabelle Ader, Laetitia Ligat, Anthony K Henras, Yasufumi Sato, Angelo Parini, Eric Lacazette, Barbara Garmy-Susini, Anne-Catherine Prats   +14 more
doaj   +1 more source

Dissecting the expression relationships between RNA-binding proteins and their cognate targets in eukaryotic post-transcriptional regulatory networks [PDF]

, 2016
RNA-binding proteins (RBPs) are pivotal in orchestrating several steps in the metabolism of RNA in eukaryotes thereby controlling an extensive network of RBP-RNA interactions. Here, we employed CLIP (cross-linking immunoprecipitation)-seq datasets for 60
Janga, Sarath Chandra, Neelamraju, Yaseswini, Nishtala, Sneha   +2 more
core   +1 more source

Translational landscape during seed germination revealed by ribosome profiling

The Plant Journal, Volume 125, Issue 1, January 2026.
SUMMARY Seed germination is crucial for agricultural reproduction. A deep understanding of this process can secure healthy growth at the early phases of plant development and therefore yield. Recent research indicates that germination is a complex process involving translational regulation.
Bing Bai, Run Qi, Wei Song, Harm Nijveen, Leónie Bentsink   +4 more
wiley   +1 more source

Ribosome profiling reveals differences in global translational vs transcriptional gene expression changes during early Candida albicans biofilm formation

Microbiology Spectrum
Candida albicans, a major human fungal pathogen, can form biofilms on a variety of inert and biological surfaces. C. albicans biofilms allow for immune evasion, are highly resistant to antifungal therapies, and represent a significant complication for a ...
Vasanthakrishna Mundodi, Saket Choudhary, Andrew D. Smith, David Kadosh   +3 more
doaj   +1 more source

A versatile method for cell-specific profiling of translated mRNAs in Drosophila. [PDF]

PLoS ONE, 2012
In Drosophila melanogaster few methods exist to perform rapid cell-type or tissue-specific expression profiling. A translating ribosome affinity purification (TRAP) method to profile actively translated mRNAs has been developed for use in a number of ...
Amanda Thomas, Pei-Jung Lee, Justin E Dalton, Krystle J Nomie, Loredana Stoica, Mauro Costa-Mattioli, Peter Chang, Sergey Nuzhdin, Michelle N Arbeitman, Herman A Dierick   +9 more
doaj   +1 more source

Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host

Aging and Cancer, Volume 6, Issue 4, Page 93-105, December 2025.
Colorectal cancer (CRC) mortality is highest in aged males. Pre‐clinical data comparing CRC i.p. metastasis in cohorts of young and aged, male and female mice support these finding. Bottom‐up proteomics of peritoneal mesothelial cells identified PTP4A1 as highly expressed in aged males and a role for PTP4A1 in heterotypic cell:cell adhesion was ...
Zhikun Wang, Yueying Liu, Jing Yang, Tyvette S. Hilliard, Reihaneh Safavi‐Sohi, Daniel D. Hu, Elizabeth I. Harper, Gena Dominique, Wanrui Wang, Jeffrey Johnson, Marwa Asem, William Milosevich, Julia Florek Carlson, Yunpeng Bai, Jinmin Miao, Zhong‐Yin Zhang, Matthew M. Champion, M. Sharon Stack   +17 more
wiley   +1 more source