Results 81 to 90 of about 361 (118)

RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress

BMC Genomics, 2019
Background Aging is accompanied with loss of tissue homeostasis and accumulation of cellular damages. As one of the important metabolic centers, liver shows age-related dysregulation of lipid metabolism, impaired detoxification pathway, increased ...
Kerui Huang, Wenhao Chen, Fang Zhu, Patrick Wai-Lun Li, Pankaj Kapahi, Hua Bai   +5 more
doaj   +1 more source

The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)

Nature Communications, 2016
Bacteria of the genus Streptomyces produce a great variety of natural products, the biosynthesis of which is subject to complex regulatory networks. Here the authors present a high-resolution, genome-wide analysis of the transcriptome and translatome of ...
Yujin Jeong, Ji-Nu Kim, Min Woo Kim, Giselda Bucca, Suhyung Cho, Yeo Joon Yoon, Byung-Gee Kim, Jung-Hye Roe, Sun Chang Kim, Colin P. Smith, Byung-Kwan Cho   +10 more
doaj   +1 more source

Integrative analyses of translatome and transcriptome reveal important translational controls in brown and white adipose regulated by microRNAs

Scientific Reports, 2017
The epidemic of obesity and diabetes has markedly spurred the research interest in adipocyte biology. Brown adipocytes are specialized for energy expenditure and of therapeutic interest for treatment of metabolic diseases, but how brown adipocytes are ...
David W. Reid, Dan Xu, Peng Chen, Hongyuan Yang, Lei Sun   +4 more
doaj   +1 more source

Local translatome sustains synaptic function in impaired Wallerian degeneration

EMBO Reports
After injury, severed axons separated from their somas activate programmed axon degeneration, a conserved pathway to initiate their degeneration within a day.
Maria Paglione, Leonardo Restivo, Sarah Zakhia, Arnau Llobet Rosell, Marco Terenzio, Lukas J Neukomm   +5 more
doaj   +1 more source

Isolating and Characterizing the Translatome From Human Alzheimer's Disease (AD) Brains

BJPsych Open
Aims Local protein synthesis at the synapse is a key determinant of learning and memory and is predicted to be severely disrupted in Alzheimer's disease (AD).
Muhammad Ali Bangash, Julie Qiaojin Lin
doaj   +1 more source

Novel 4D Tensor Decomposition-Based Approach Integrating Tri-Omics Profiling Data Can Identify Functionally Relevant Gene Clusters

Biology
Understanding gene expression requires integrating multiple regulatory layers, because transcript abundance does not necessarily correspond to translational activity or protein abundance.
Turki Turki, Y.-H. Taguchi
doaj   +1 more source

Citrus phloem specific transcriptional profiling through the development of a citrus tristeza virus expressed translating ribosome affinity purification system

Plant Methods
Background The analysis of translationally active mRNAs, or translatome, is a useful approach for monitoring cellular and plant physiological responses.
James N. Culver, Meinhart Vallar, Erik Burchard, Sophie Kamens, Sebastien Lair, Yiping Qi, Tamara D. Collum, Christopher Dardick, Choaa A. El-Mohtar, Elizabeth E. Rogers   +9 more
doaj   +1 more source

Queuosine tRNA Modification: Connecting the Microbiome to the Translatome

BioEssays
ABSTRACTTransfer RNA (tRNA) modifications play an important role in regulating mRNA translation at the codon level. tRNA modifications can influence codon selection and optimality, thus shifting translation toward specific sets of mRNAs in a dynamic manner. Queuosine (Q) is a tRNA modification occurring at the wobble position.
openaire   +2 more sources

Editorial: Relevance of Translational Regulation on Plant Growth and Environmental Responses

Frontiers in Plant Science, 2017
Alejandro Ferrando, M. Mar Castellano, Purificación Lisón, Dario Leister, Anna N. Stepanova, Johannes Hanson   +5 more
doaj   +1 more source

How to discover new proteins—translatome profiling

Science China Life Sciences, 2014
Zhang, Gong, Wang, Tong, He, QingYu
openaire   +2 more sources