Results 81 to 90 of about 4,258 (187)

Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

, 2021
Tactical disruption of protein synthesis is an attractive therapeutic strategy, with the first-in-class eIF4A-targeting compound zotatifin in clinical evaluation for cancer and COVID-19.
Krieger, Jonathan R, Manara, Paola, Roberts, Evan R, Osteen, Ashanti, Bilbao, Daniel, Arumov, Artavazd, Kumar, Preet, Ho, J.J. David, Cunningham, Tyler A, Coughlin, Caroline A, Schatz, Jonathan H, Lee, Stephen   +11 more
core   +1 more source

Rapid CO2 effects on protein‐related metabolism during photosynthetic gas exchange

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY It is common practice to vary atmospheric CO2 mole fraction (Ca) during gas exchange experiments to manipulate photorespiration and explore photosynthetic properties such as maximum carboxylation velocity. In doing so, it is assumed that changing Ca essentially alters the carboxylation‐to‐oxygenation ratio, with negligible effects on other ...
Corentin Dourmap, Cyril Abadie, Marlène Davanture, Willy Bienvenut, Julie Lalande, Guillaume Tcherkez   +5 more
wiley   +1 more source

Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

eLife, 2019
Hypoxia, a major inducer of angiogenesis, triggers major changes in gene expression at the transcriptional level. Furthermore, under hypoxia, global protein synthesis is blocked while internal ribosome entry sites (IRES) allow specific mRNAs to be ...
Fransky Hantelys, Anne-Claire Godet, Florian David, Florence Tatin, Edith Renaud-Gabardos, Françoise Pujol, Leila H Diallo, Isabelle Ader, Laetitia Ligat, Anthony K Henras, Yasufumi Sato, Angelo Parini, Eric Lacazette, Barbara Garmy-Susini, Anne-Catherine Prats   +14 more
doaj   +1 more source

Sex‐ and Region‐Specific Glial Reactivity in Hyperthyroid Mice Lacks Correlation With the Noncognitive and Non‐Depressive‐Like Behavioral Alterations

Brain and Behavior, Volume 16, Issue 6, June 2026.
Hyperthyroidism induces sex‐ and region‐specific glial reactivity without correlation to the noncognitive, non‐depressive behavioral changes in mice. ABSTRACT Background Glial reactivity is implicated in hyperthyroidism‐associated cognitive and psychiatric disorders, yet in vivo imaging evidence of glial reactivity in hyperthyroidism remains to be ...
Qianqian Xue, Zefang Lin, Yaofeng Wang, Xiuting Lin, Yun Yang, Chao Wang, Yuhong Ye, Weibing Miao   +7 more
wiley   +1 more source

Reprogramming the translatome during daily light transitions as affected by cytosolic glyceraldehyde-3-phosphate dehydrogenase GAPC1/C2

, 2023
Wegener M, Persicke M, Dietz K-J. Reprogramming the translatome during daily light transitions as affected by cytosolic glyceraldehyde-3-phosphate dehydrogenase GAPC1/C2. Journal of Experimental Botany .
Dietz, Karl-Josef, Persicke, Marcus, Wegener, Melanie   +2 more
core   +1 more source

tRanslatome: an R/Bioconductor package to portray translational control [PDF]

Bioinformatics, 2013
Abstract Summary: High-throughput technologies have led to an explosion of genomic data available for automated analysis. The consequent possibility to simultaneously sample multiple layers of variation along the gene expression flow requires computational methods integrating raw information from different ‘-omics’.
Toma Tebaldi, Erik Dassi, Galena Kostoska, Gabriella Viero, Alessandro Quattrone   +4 more
openaire   +4 more sources

Ribosome profiling reveals differences in global translational vs transcriptional gene expression changes during early Candida albicans biofilm formation

Microbiology Spectrum
Candida albicans, a major human fungal pathogen, can form biofilms on a variety of inert and biological surfaces. C. albicans biofilms allow for immune evasion, are highly resistant to antifungal therapies, and represent a significant complication for a ...
Vasanthakrishna Mundodi, Saket Choudhary, Andrew D. Smith, David Kadosh   +3 more
doaj   +1 more source

Solanesol Alleviates Perfluoroheptanoic Acid‐Induced Premature Senescence in Human Skin Fibroblasts via RNA Methylation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Perfluoroheptanoic acid (PFHpA) induces premature senescence in normal human skin fibroblasts (HSFs), as characterized by decreased cell viability, increased SA‐β‐gal staining, impaired wound healing, cell cycle dysregulation, elevated ROS levels, and upregulated SASP mRNA expression.
Jiaqi Fu, Tingting Huang, Guisong Li, Xinyu Zhang, Luyi Tan, Chenyu Zhu, Wenji Zhang, Wenjuan Zhang   +7 more
wiley   +1 more source

Glia Are Bussin’: How Single‐Cell and Spatial Transcriptomics Enlighten the Role of Neuroglia in Spinal Cord Injury and Regeneration

Glia, Volume 74, Issue 6, June 2026.
Neuroglia have been extensively profiled using single‐cell genomics, improving our understanding of their dynamics after spinal cord injury. A meta‐analysis of five single‐cell time‐course genomic studies reveals heterogeneity underscoring important challenges for interpretation.
Julio Mejia, Philip J. Horner
wiley   +1 more source

Additional file 4: of Selective translational usage of TSS and core promoters revealed by translatome sequencing

, 2019
Table S2. Length difference of the 5’ UTR between translatome and transcriptome. “Length Difference” shows the difference in length of the 5’ UTR. “Length Status” shows whether the length of the 5’UTR in translatome is the same as, or shorter than, or ...
Jielin Sun (123338), Hua Li (46469), Xinhui Li (349485), Ling Bai (82594), Hongmei Li (51944), Zhifeng Shao (698979), Yani Kang (698978), Ningbo Zhang (591333)   +7 more
core   +1 more source